Targeting dengue virus ns4b protein for drug discovery
文献类型：期刊论文
| 作者 | Xie, Xuping1; Zou, Jing1,2,3; Wang, Qing-Yin1; Shi, Pei-Yong1 |
| 刊名 | Antiviral research
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 118页码:39-45 |
| 关键词 | Flavivirus Dengue Nonstructural protein 4b Ns4b Antivirals |
| ISSN号 | 0166-3542 |
| DOI | 10.1016/j.antiviral.2015.03.007 |
| 通讯作者 | Wang, qing-yin(qing_yin.wang@novartis.com) |
| 英文摘要 | The flavivirus nonstructural 4b protein (ns4b) has recently emerged as a valid antiviral target for drug discovery. here we review (i) the current understanding of the structure and function of denv ns4b, (ii) the approaches that have been taken to identify ns4b inhibitors, and (iii) the known inhibitors of flavivirus ns4b protein. this article forms part of a symposium in antiviral research on flavivirus drug discovery. (c) 2015 elsevier b.v. all rights reserved. |
| WOS关键词 | WEST-NILE-VIRUS ; NONSTRUCTURAL PROTEINS ; CRYSTAL-STRUCTURE ; MEMBRANE-ALTERATIONS ; REPLICATION COMPLEX ; CATALYTIC DOMAIN ; RNA REPLICATION ; STRANDED-RNA ; INHIBITION ; NS3 |
| WOS研究方向 | Pharmacology & Pharmacy ; Virology |
| WOS类目 | Pharmacology & Pharmacy ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000355037500005 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375176 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Wang, Qing-Yin |
| 作者单位 | 1.Novartis Inst Trop Dis, Singapore 138670, Singapore 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Beijing 100864, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Xuping,Zou, Jing,Wang, Qing-Yin,et al. Targeting dengue virus ns4b protein for drug discovery[J]. Antiviral research,2015,118:39-45. |
| APA | Xie, Xuping,Zou, Jing,Wang, Qing-Yin,&Shi, Pei-Yong.(2015).Targeting dengue virus ns4b protein for drug discovery.Antiviral research,118,39-45. |
| MLA | Xie, Xuping,et al."Targeting dengue virus ns4b protein for drug discovery".Antiviral research 118(2015):39-45. |
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来源：武汉病毒研究所
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