Ev71 infection correlates with viral igg preexisting at pharyngolaryngeal mucosa in children
文献类型：期刊论文
| 作者 | Xue, Jingchang2; Li, Yaoming1; Xu, Xiaoyi2; Yu, Jie1; Yan, Hu1; Yan, Huimin1 |
| 刊名 | Virologica sinica
 |
| 出版日期 | 2015-04-01 |
| 卷号 | 30期号:2页码:146-152 |
| ISSN号 | 1674-0769 |
| 关键词 | Ev71 Clinical infection Mucosal igg Vp1 Vp2 3d |
| DOI | 10.1007/s12250-014-3555-2 |
| 通讯作者 | Li, yaoming(liym@wh.iov.cn) |
| 英文摘要 | Enterovirus 71 (ev71) infection causes severe central nervous system damage, particularly for children under the age of 5 years old, which remains a major public health burden worldwide. clinical data released that children may be repeatedly infected by different members in enterovirus and get even worsen. mucosa, especially epithelium of alimentary canal, was considered the primary site of ev71 infection. it has been elusive whether the preexsiting viral antibody in mucosa plays a role in ev71 infection. to answer this question, we respectively measured viral antibody response and ev71 rna copy number of one hundred throat swab specimens from clinically confirmed ev71-infected children. the results released that low-level of mucosal igg antibody against ev71 broadly existed in young population. more importantly, it further elucidated that the children with mucosal preexsiting ev71 igg were prone to be infected, which suggested a former viral igg mediated enhancement of viral infection in vivo. |
| WOS关键词 | ANTIBODY-DEPENDENT ENHANCEMENT ; ENTEROVIRUS 71 INFECTION ; MOUTH-DISEASE ; VIRUS-INFECTION ; RECEPTOR ; HAND ; FOOT ; EFFICACY ; VACCINE ; PROTEIN |
| 语种 | 英语 |
| 出版者 | SPRINGER |
| WOS记录号 | WOS:000355983400008 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375184 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Li, Yaoming |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Mucosal Immun Res Grp, Wuhan 430071, Peoples R China 2.Changzhou Ctr Dis Control & Prevent, Changzhou 213022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xue, Jingchang,Li, Yaoming,Xu, Xiaoyi,et al. Ev71 infection correlates with viral igg preexisting at pharyngolaryngeal mucosa in children[J]. Virologica sinica,2015,30(2):146-152. |
| APA | Xue, Jingchang,Li, Yaoming,Xu, Xiaoyi,Yu, Jie,Yan, Hu,&Yan, Huimin.(2015).Ev71 infection correlates with viral igg preexisting at pharyngolaryngeal mucosa in children.Virologica sinica,30(2),146-152. |
| MLA | Xue, Jingchang,et al."Ev71 infection correlates with viral igg preexisting at pharyngolaryngeal mucosa in children".Virologica sinica 30.2(2015):146-152. |
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来源：武汉病毒研究所
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