Celecoxib inhibits the lytic activation of kaposi's sarcoma-associated herpesvirus through down-regulation of rta expression by inhibiting the activation of p38 mapk
文献类型：期刊论文
| 作者 | Chen, Jungang1,2; Jiang, Liangyu1,2; Lan, Ke3; Chen, Xulin1,2 |
| 刊名 | Viruses-basel
 |
| 出版日期 | 2015-05-01 |
| 卷号 | 7期号:5页码:2268-2287 |
| ISSN号 | 1999-4915 |
| DOI | 10.3390/v7052268 |
| 通讯作者 | Chen, xulin(chenxl@wh.iov.cn) |
| 英文摘要 | Kaposi's sarcoma associated herpesvirus (kshv) is the etiologic agent of kaposi's sarcoma (ks), primary effusion lymphoma (pel), and multicentric castleman's disease (mcd). kshv's lytic replication cycle is critical for the pathogenesis of kshv-associated diseases. despite recent progress in the development of treatments for kshv associated malignancies, these therapies are not completely efficacious and cause side effects. therefore, more effective therapies with antiviral agents against kshv are urgently needed. in this study, we identified celecoxib as an antiviral agent against kshv. our data suggest that celecoxib inhibits the lytic activation of kshv through the down-regulation of the expression of the lytic switch protein, replication and transcription activator (rta), by inhibiting the activation of p38 mapk. therefore, celecoxib may provide a candidate inhibitor for the therapeutic research of kshv-related malignancies. |
| WOS关键词 | NF-KAPPA-B ; PRIMARY EFFUSION LYMPHOMA ; PROTEIN-KINASE PATHWAYS ; SELECTIVE COX-2 INHIBITORS ; EPSTEIN-BARR-VIRUS ; GENE-EXPRESSION ; PRIMARY INFECTION ; IN-VITRO ; QUANTITATIVE-ANALYSIS ; ENDOTHELIAL-CELLS |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000356228700004 |
| 出版者 | MDPI AG |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375185 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Chen, Xulin |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 43001, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Pasteur Shanghai, Shanghai Inst Biol Sci, Key Lab Mol Virol & Immunol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Jungang,Jiang, Liangyu,Lan, Ke,et al. Celecoxib inhibits the lytic activation of kaposi's sarcoma-associated herpesvirus through down-regulation of rta expression by inhibiting the activation of p38 mapk[J]. Viruses-basel,2015,7(5):2268-2287. |
| APA | Chen, Jungang,Jiang, Liangyu,Lan, Ke,&Chen, Xulin.(2015).Celecoxib inhibits the lytic activation of kaposi's sarcoma-associated herpesvirus through down-regulation of rta expression by inhibiting the activation of p38 mapk.Viruses-basel,7(5),2268-2287. |
| MLA | Chen, Jungang,et al."Celecoxib inhibits the lytic activation of kaposi's sarcoma-associated herpesvirus through down-regulation of rta expression by inhibiting the activation of p38 mapk".Viruses-basel 7.5(2015):2268-2287. |
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来源：武汉病毒研究所
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