Molecular evolution of the sars coronavirus during the course of the sars epidemic in china
文献类型：期刊论文
| 作者 | He, JF; Peng, GW; Min, J; Yu, DW; Liang, WJ; Zhang, SY; Xu, RH; Zheng, HY; Wu, XW; Xu, J |
| 刊名 | Science
 |
| 出版日期 | 2004-03-12 |
| 卷号 | 303期号:5664页码:1666-1669 |
| ISSN号 | 0036-8075 |
| DOI | 10.1126/science.1092002 |
| 通讯作者 | Zhao, gp(gpzhao@ibs.ac.cn) |
| 英文摘要 | Sixty-one sars coronavirus genomic sequences derived from the early, middle, and late phases of the severe acute respiratory syndrome ( sars) epidemic were analyzed together with two viral sequences from palm civets. genotypes characteristic of each phase were discovered, and the earliest genotypes were similar to the animal sars-like coronaviruses. major deletions were observed in the orf8 region of the genome, both at the start and the end of the epidemic. the neutral mutation rate of the viral genome was constant but the amino acid substitution rate of the coding sequences slowed during the course of the epidemic. the spike protein showed the strongest initial responses to positive selection pressures, followed by subsequent purifying selection and eventual stabilization. |
| WOS关键词 | ACUTE-RESPIRATORY-SYNDROME ; HONG-KONG ; GENOME SEQUENCE ; AMOY GARDENS ; VIRUS ; OUTBREAK ; IDENTIFICATION ; VIRULENCE ; MUTATION ; RATES |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| WOS记录号 | WOS:000220151400043 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375186 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zhao, GP |
| 作者单位 | 1.Chinese Natl Human Genome Ctr Shanghai, Shanghai 201203, Peoples R China 2.Shanghai Med Univ 2, Ruijin Hosp, State Key Lab Med Genom Pole Sino Francais Rech S, Shanghai 200025, Peoples R China 3.Guangdong Ctr Dis Control & Prevent, Guangzhou 510300, Guangdong, Peoples R China 4.Sun Yat Sen Univ, Affiliated Hosp 2, Guangzhou 510120, Guangdong, Peoples R China 5.Chinese Acad Sci, Inst Zool, Beijing 100080, Peoples R China 6.Guangzhou Ctr Dis Control & Prevent, Guangzhou 510080, Guangdong, Peoples R China 7.Guangzhou Inst Resp Dis, Guangzhou 510120, Guangdong, Peoples R China 8.First Med Univ, Nanfang Hosp, Dept Infect Dis & Mol Immunol, Guangzhou 510515, Guangdong, Peoples R China 9.Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Hubei, Peoples R China 10.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200030, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, JF,Peng, GW,Min, J,et al. Molecular evolution of the sars coronavirus during the course of the sars epidemic in china[J]. Science,2004,303(5664):1666-1669. |
| APA | He, JF.,Peng, GW.,Min, J.,Yu, DW.,Liang, WJ.,...&Lo, YMD.(2004).Molecular evolution of the sars coronavirus during the course of the sars epidemic in china.Science,303(5664),1666-1669. |
| MLA | He, JF,et al."Molecular evolution of the sars coronavirus during the course of the sars epidemic in china".Science 303.5664(2004):1666-1669. |
入库方式： iSwitch采集
来源：武汉病毒研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。