808 nm photocontrolled ucl imaging guided chemo/photothermal synergistic therapy with single ucnps-cus@paa nanocomposite
文献类型：期刊论文
| 作者 | Liu, Bei1,3; Li, Chunxia1; Xie, Zhongxi1,3; Hou, Zhiyao1; Cheng, Ziyong1; Jin, Dayong2; Lin, Jun1 |
| 刊名 | Dalton transactions
 |
| 出版日期 | 2016-09-07 |
| 卷号 | 45期号:33页码:13061-13069 |
| ISSN号 | 1477-9226 |
| DOI | 10.1039/c5dt04857e |
| 通讯作者 | Li, chunxia(cxli@ciac.ac.cn) ; Lin, jun(jlin@ciac.ac.cn) |
| 英文摘要 | Recently, incorporating multiple components into one nanostructured matrix to construct a multifunctional nanomedical platform has attracted more and more attention for simultaneous anticancer diagnosis and therapy. herein, a novel anti-cancer nanoplatform has been successfully developed by coating a uniform shell of poly(acrylic acid) (paa) on the surface of cus-decorated upconversion nanoparticles (ucnps). benefiting from the enhanced 808 nm-excited ucl intensity of the multilayer ucnps, the unique photothermal properties of cus and the ph-responsive drug release capacity of the paa shell, such a nanoplatform design of ucnps-cus@paa (labeled ucp) offers a new route to achieve 808 nm-excited ucl imaging guided chemo/photothermal combination therapy. we have found that the combined chemo/photothermal therapy can significantly improve the therapeutic efficacy compared with chemotherapy or photothermal therapy (ptt) alone. moreover, the ph/nir-dependent drug delivery properties, 808 nm-excited ucl imaging, as well as in vitro/in vivo biocompatibility tests were also investigated in detail. these results show promising applications of ucp nanoparticles as a novel theranostic agent for the detection and treatment of tumors. |
| WOS关键词 | UP-CONVERSION NANOPARTICLES ; ANTICANCER DRUG-DELIVERY ; PHOTOTHERMAL THERAPY ; IN-VIVO ; CANCER-CELLS ; SILICA ; NANOMATERIALS ; PLATFORM ; DESIGN ; COMBINATION |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Inorganic & Nuclear |
| 语种 | 英语 |
| WOS记录号 | WOS:000382135400014 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375196 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Li, Chunxia; Lin, Jun |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China 2.Univ Technol Sydney, Fac Sci, Inst Biomed Mat & Devices, Sydney, NSW 2007, Australia 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Bei,Li, Chunxia,Xie, Zhongxi,et al. 808 nm photocontrolled ucl imaging guided chemo/photothermal synergistic therapy with single ucnps-cus@paa nanocomposite[J]. Dalton transactions,2016,45(33):13061-13069. |
| APA | Liu, Bei.,Li, Chunxia.,Xie, Zhongxi.,Hou, Zhiyao.,Cheng, Ziyong.,...&Lin, Jun.(2016).808 nm photocontrolled ucl imaging guided chemo/photothermal synergistic therapy with single ucnps-cus@paa nanocomposite.Dalton transactions,45(33),13061-13069. |
| MLA | Liu, Bei,et al."808 nm photocontrolled ucl imaging guided chemo/photothermal synergistic therapy with single ucnps-cus@paa nanocomposite".Dalton transactions 45.33(2016):13061-13069. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。