Selective cyclooxygenase-2 inhibitors from calophyllum membranaceum
文献类型：期刊论文
| 作者 | Zou, J; Jin, DZ; Chen, WL; Wang, J; Liu, QF; Zhu, XZ; Zhao, WM |
| 刊名 | Journal of natural products
 |
| 出版日期 | 2005-10-01 |
| 卷号 | 68期号:10页码:1514-1518 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np0502342 |
| 通讯作者 | Zhu, xz(wmzhao@mail.shcnc.ac.cn) |
| 英文摘要 | Chemical investigation of the anti-inflammatory chinese folk medicine calophyllum membranaceum has resulted in the isolation and characterization of three new xanthones (1-3), one new biphenyl c-glycoside (4), and one new phenylethanoid glycoside (5) along with 17 known compounds. their structures were characterized on the basis of spectroscopic and chemical methods. two xanthones, 2,6-dihydroxy-1,7-dimethoxyxanthone (1) and 3,4-dihydroxyxanthone, were found to exhibit selective inhibitory activity against cyclooxygenase-2 (ic50 = 2.99 and 1.80 mu m) in vitro. |
| WOS关键词 | TEYSMANNII VAR. INOPHYLLOIDE ; XANTHONE DERIVATIVES ; CEYLONESE PLANTS ; NATURAL-PRODUCTS ; ROOT BARK ; GUTTIFERAE ; EXTRACTIVES ; CHEMISTRY ; LANIGERUM |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| WOS类目 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000233211800012 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375201 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Dept Pharmacol, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Dept Nat Prod, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zou, J,Jin, DZ,Chen, WL,et al. Selective cyclooxygenase-2 inhibitors from calophyllum membranaceum[J]. Journal of natural products,2005,68(10):1514-1518. |
| APA | Zou, J.,Jin, DZ.,Chen, WL.,Wang, J.,Liu, QF.,...&Zhao, WM.(2005).Selective cyclooxygenase-2 inhibitors from calophyllum membranaceum.Journal of natural products,68(10),1514-1518. |
| MLA | Zou, J,et al."Selective cyclooxygenase-2 inhibitors from calophyllum membranaceum".Journal of natural products 68.10(2005):1514-1518. |
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来源：武汉病毒研究所
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