Liquid chromatography/tandem mass spectrometry for the determination of magnesium lithospermate b in beagle dog serum
文献类型：期刊论文
| 作者 | Li, XC; Yu, C; Sun, WK; Lu, J; Xuan, LJ; Wang, YP |
| 刊名 | Journal of pharmaceutical and biomedical analysis
 |
| 出版日期 | 2005-06-01 |
| 卷号 | 38期号:1页码:107-111 |
| 关键词 | Lc/ms/ms Pharmacokinetics Mlb Beagle dogs |
| ISSN号 | 0731-7085 |
| DOI | 10.1016/j.jpba.2004.11.054 |
| 通讯作者 | Wang, yp() |
| 英文摘要 | A sensitive and specific isocratic liquid chromatography/tandem mass spectrometry (lc/ms/ms) method was developed for the quantification of magnesium lithospermate b (mlb) in beagle dog serum with silibinin as internal standard. the serum samples were treated by special liquid-liquid extraction, and the analytes were determined using electrospray negative ionization mass spectrometry in the selective monitoring mode, with sufficient sensitivity to allow analysis of dog serum samples generated following administration of a clinically relevant dose. the calibration curve for mlb was linear over the range 8-2048 ng/ml with coefficients of correlation > 0.999. the intra- and inter-day precisions (cv) of analysis were < 7%, and accuracy ranged from 90 to 106%. this quantitation method was successfully applied to a pharmacokinetic study of i.h. administration of mlb with dosages of 3, 6, 12 mg/kg in beagle dogs. (c) 2004 elsevier b.v all rights reserved. |
| WOS关键词 | SALVIAE-MILTIORRHIZAE RADIX ; TANSHINOATE-B ; INHIBITION ; RELEASE ; RATS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Analytical ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000230017500017 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375220 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Wang, YP |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Phytochem, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100864, Peoples R China 4.Shanghai Xuhui Cent Hosp, Cent Lab, Shanghai 200002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, XC,Yu, C,Sun, WK,et al. Liquid chromatography/tandem mass spectrometry for the determination of magnesium lithospermate b in beagle dog serum[J]. Journal of pharmaceutical and biomedical analysis,2005,38(1):107-111. |
| APA | Li, XC,Yu, C,Sun, WK,Lu, J,Xuan, LJ,&Wang, YP.(2005).Liquid chromatography/tandem mass spectrometry for the determination of magnesium lithospermate b in beagle dog serum.Journal of pharmaceutical and biomedical analysis,38(1),107-111. |
| MLA | Li, XC,et al."Liquid chromatography/tandem mass spectrometry for the determination of magnesium lithospermate b in beagle dog serum".Journal of pharmaceutical and biomedical analysis 38.1(2005):107-111. |
入库方式： iSwitch采集
来源：武汉病毒研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。