Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine a(1) receptor in a manner different from its classical agonists
文献类型：期刊论文
| 作者 | Liu, DZ; Xie, KQ; Ji, XQ; Ye, Y; Jiang, CL; Zhu, XZ |
| 刊名 | British journal of pharmacology
 |
| 出版日期 | 2005-10-01 |
| 卷号 | 146期号:4页码:604-611 |
| 关键词 | Paeoniflorin Neuroprotective effect Adenosine a(1) receptor Transient cerebral ischemia Permanent cerebral ischemia Cardiovascular side effect |
| ISSN号 | 0007-1188 |
| 通讯作者 | Zhu, xz() |
| 英文摘要 | 1 the effects of paeoniflorin (pf), a compound isolated from paeony radix, on neurological impairment and histologically measured infarction volume following transient and permanent focal ischemia were examined in sprague-dawley rats. 2 in transient ischemia model, rats were subjected to a 1.5-h occlusion of the middle cerebral artery (mca). the administration of pf (2.5 and 5 mg kg(-1), s.c.) produced a dose-dependent decrease in both neurological impairment and the histologically measured infarction volume. similar results were also obtained when pf (2.5, 5, and 10 mg kg(-1), s.c.) was given in permanent ischemia model. 3 the neuroprotective effect of pf (10mg kg(-1), s.c.) was abolished by pretreatment of dpcpx (0.25 mg kg(-1), s.c.), a selective adenosine a, receptor (air) antagonist. 4 pf (10, 40, and 160 mg kg(-1), i.v.) had no effect on mean arterial pressure (map) and heart rates (hr) in the conscious rat. additionally, pf (10(-3) mol l(-1)) had no effect on noradrenaline- (na-) or high k+ concentration-induced contractions of isolated rabbit primary artery. 5 in competitive binding experiments, pf did not compete with the binding of [h-3]dpcpx, but displaced the binding of [h-3]neca to the membrane preparation of rat cerebral cortex. this binding manner was distinguished from the classical a(1)r agonists. 6 the results demonstrated that activation of a(1)r might be involved in pf-induced neuroprotection in cerebral ischemia in rat. however, pf had no 'well-known' cardiovascular side effects of classical a(1)r agonists. the results suggest that pf might have the potential therapeutic value as an anti-stroke drug. |
| WOS关键词 | ARTERY OCCLUSION ; WHITE ADIPOCYTES ; WISTAR RATS ; IN-VIVO ; MODULATION ; PERMANENT ; RELEASE ; NEURONS ; BINDING ; PROTEIN |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000232785200017 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375247 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, DZ,Xie, KQ,Ji, XQ,et al. Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine a(1) receptor in a manner different from its classical agonists[J]. British journal of pharmacology,2005,146(4):604-611. |
| APA | Liu, DZ,Xie, KQ,Ji, XQ,Ye, Y,Jiang, CL,&Zhu, XZ.(2005).Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine a(1) receptor in a manner different from its classical agonists.British journal of pharmacology,146(4),604-611. |
| MLA | Liu, DZ,et al."Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine a(1) receptor in a manner different from its classical agonists".British journal of pharmacology 146.4(2005):604-611. |
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来源：武汉病毒研究所
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