Protection of inactivated influenza virus vaccine against lethal influenza virus infection in diabetic mice
文献类型：期刊论文
| 作者 | Zhu, Q; Chang, HY; Chen, Y; Fang, F; Xue, CY; Zhang, FH; Qiu, MZ; Wang, HZ; Wang, B; Chen, Z |
| 刊名 | Biochemical and biophysical research communications
 |
| 出版日期 | 2005-04-01 |
| 卷号 | 329期号:1页码:87-94 |
| 关键词 | Diabetes mellitus Influenza virus Vaccine |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2005.01.109 |
| 通讯作者 | Chen, z(chenze2005@263.net) |
| 英文摘要 | Influenza virus infection frequently causes complications and some excess mortality in the patients with diabetes. vaccination is an effective measure to prevent influenza virus infection. in this paper, antibody response and protection against influenza virus infection induced by vaccination were studied in mouse model of diabetes. healthy and diabetic balb/c mice were immunized once or twice with inactivated influenza virus vaccine at various dosages. four weeks after the first immunization or 1 week after the second immunization. the mice were challenged with influenza virus at a lethal dose. the result showed that the antibody responses in diabetic mice were inhibited. immunization once with high dose or twice with low dose of vaccine provided full protection against lethal influenza virus challenge in diabetic mice, however, in healthy mice, immunization only once with low dose provided a full protection. (c) 2005 elsevier inc. all rights reserved. |
| WOS关键词 | ANTIBODY-RESPONSES ; IMMUNE-RESPONSES ; PLASMID DNAS ; MELLITUS ; STREPTOZOTOCIN ; MORTALITY ; ADULTS ; HEMAGGLUTININ ; IMMUNIZATION ; PNEUMONIA |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000227415700014 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375249 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Chen, Z |
| 作者单位 | 1.Hunan Normal Univ, Coll Life Sci, Changsha 410081, Hunan, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Hubei, Peoples R China 3.Gen Hosp PLA, Beijing 100853, Peoples R China 4.China Agr Univ, Coll Biol Sci, State Key Lab Agrobiotechnol, Beijing 100094, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Q,Chang, HY,Chen, Y,et al. Protection of inactivated influenza virus vaccine against lethal influenza virus infection in diabetic mice[J]. Biochemical and biophysical research communications,2005,329(1):87-94. |
| APA | Zhu, Q.,Chang, HY.,Chen, Y.,Fang, F.,Xue, CY.,...&Chen, Z.(2005).Protection of inactivated influenza virus vaccine against lethal influenza virus infection in diabetic mice.Biochemical and biophysical research communications,329(1),87-94. |
| MLA | Zhu, Q,et al."Protection of inactivated influenza virus vaccine against lethal influenza virus infection in diabetic mice".Biochemical and biophysical research communications 329.1(2005):87-94. |
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来源：武汉病毒研究所
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