The calponin family member chdp-1 interacts with rac/ced-10 to promote cell protrusions
文献类型：期刊论文
| 作者 | Guan, Liying1; Ma, Xuehua1,2; Zhang, Jingyan1,2; Liu, Jia-Jia1,3; Wang, Yingchun1; Ding, Mei1,3 |
| 刊名 | Plos genetics
 |
| 出版日期 | 2016-07-01 |
| 卷号 | 12期号:7页码:20 |
| ISSN号 | 1553-7404 |
| DOI | 10.1371/journal.pgen.1006163 |
| 通讯作者 | Ding, mei(mding@genetics.ac.cn) |
| 英文摘要 | Eukaryotic cells extend a variety of surface protrusions to direct cell motility. formation of protrusions is mediated by coordinated actions between the plasma membrane and the underlying actin cytoskeleton. here, we found that the single calponin homology (ch) domain-containing protein chdp-1 induces the formation of cell protrusions in c. elegans. chdp-1 is anchored to the cortex through its amphipathic helix. chdp-1 associates through its ch domain with the small gtpase rac1/ced-10, which is a key regulator of the actin cytoskeleton. chdp-1 preferentially binds to the gtp-bound active form of the ced-10 protein and preserves the membrane localization of gtp-ced-10. hence, by coupling membrane expansion to rac1-mediated actin dynamics, chdp-1 promotes the formation of cellular protrusions in vivo. |
| WOS关键词 | ACTIN-BINDING-PROTEIN ; SWISS 3T3 FIBROBLASTS ; CAENORHABDITIS-ELEGANS ; MEMBRANE CURVATURE ; HOMOLOGY DOMAIN ; STRESS FIBERS ; ALPHA-ACTININ ; CH DOMAIN ; F-ACTIN ; RAC |
| WOS研究方向 | Genetics & Heredity |
| WOS类目 | Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000381050100030 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375275 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ding, Mei |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guan, Liying,Ma, Xuehua,Zhang, Jingyan,et al. The calponin family member chdp-1 interacts with rac/ced-10 to promote cell protrusions[J]. Plos genetics,2016,12(7):20. |
| APA | Guan, Liying,Ma, Xuehua,Zhang, Jingyan,Liu, Jia-Jia,Wang, Yingchun,&Ding, Mei.(2016).The calponin family member chdp-1 interacts with rac/ced-10 to promote cell protrusions.Plos genetics,12(7),20. |
| MLA | Guan, Liying,et al."The calponin family member chdp-1 interacts with rac/ced-10 to promote cell protrusions".Plos genetics 12.7(2016):20. |
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来源：中国科学院大学
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