Monte carlo simulation of the neurofilament brush
文献类型：期刊论文
| 作者 | Jeong, SeongMin1; Zhou, Xin2; Zhulina, Ekaterina B.3,4; Jho, YongSeok1 |
| 刊名 | Israel journal of chemistry
 |
| 出版日期 | 2016-08-01 |
| 卷号 | 56期号:8页码:599-606 |
| 关键词 | Neurofilament Phosphorylation Polyampholyte Polymers Trajectory calculations |
| ISSN号 | 0021-2148 |
| DOI | 10.1002/ijch.201400085 |
| 通讯作者 | Zhulina, ekaterina b.(kzhulina@hotmail.com) ; Jho, yongseok(ysjho@apctp.org) |
| 英文摘要 | Grand canonical monte carlo (mc) simulations are performed to analyse conformations of projection domains in a neurofilament (nf) brush composed of three types of tails (l, m, and h) at different concentrations of added salt. the nf is modelled as a rigid, uniformly charged cylinder (backbone), surrounded by tethered, flexible polyampholytic chains with charge distributions and stoichiometry similar to those in natural nfs. we calculate the equilibrium trajectory for each projection; that is, the average distance of the amino acid residue from the surface of the backbone as a function of its ranking number. these trajectories demonstrate the tendency for projections to fold back and adopt loop-like conformations at moderate solution salinities. we also perform extended analysis of mc data to identify metastable states of the system, and demonstrate representative snapshots of tail conformations in major metastable states. |
| WOS关键词 | IONIC-STRENGTH ; SIDE-ARMS ; NF-H ; PHOSPHORYLATION ; ORGANIZATION ; ARCHITECTURE ; NETWORKS ; MODEL ; AXONS |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000382715800004 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375284 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhulina, Ekaterina B.; Jho, YongSeok |
| 作者单位 | 1.POSTECH, Asia Pacific Ctr Theoret Phys, Dept Phys, Pohang, South Korea 2.Univ Chinese Acad Sci, Sch Phys, Beijing, Peoples R China 3.Russian Acad Sci, Inst Macromol Cpds, St Petersburg, Russia 4.ITMO Univ, St Petersburg, Russia |
| 推荐引用方式 GB/T 7714 | Jeong, SeongMin,Zhou, Xin,Zhulina, Ekaterina B.,et al. Monte carlo simulation of the neurofilament brush[J]. Israel journal of chemistry,2016,56(8):599-606. |
| APA | Jeong, SeongMin,Zhou, Xin,Zhulina, Ekaterina B.,&Jho, YongSeok.(2016).Monte carlo simulation of the neurofilament brush.Israel journal of chemistry,56(8),599-606. |
| MLA | Jeong, SeongMin,et al."Monte carlo simulation of the neurofilament brush".Israel journal of chemistry 56.8(2016):599-606. |
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来源：中国科学院大学
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