Group i but not group iinpv induces antiviral effects in mammalian cells
文献类型：期刊论文
| 作者 | Liang Changyong; Song Jianhua; Hu Zhihong; Chen Xinwen |
| 刊名 | Science in china series c-life sciences
 |
| 出版日期 | 2006-10-01 |
| 卷号 | 49期号:5页码:467-472 |
| 关键词 | Antiviral effect Baculovirus Vsv Ifn-alpha/beta Mammalian cells Transgene expression |
| ISSN号 | 1006-9305 |
| DOI | 10.1007/s11427-006-2023-0 |
| 通讯作者 | Chen xinwen(chenxw@wh.iov.cn) |
| 英文摘要 | Nucleopolyhedrovirus (npv) is divided into group i and group 11 based on the phylogenetic analysis. it has been reported that group i npvs such as autographa californica multiple npv (acmnpv) can transduce mammalian cells, while group 11 npvs such as helicoverpa armigera single npv (hasnpv) cannot. here we report that acmnpv was capable of stimulating antiviral activity in human hepatoma cells (smmc-7721) manifested by inhibition of vesicular stomatitis virus (vsv) replication. in contrast, the hasnpv and the spodoptera exigua multiple npv (semnpv) of group 11 had no inhibitory effect on vsv. recombinant acmnpv was shown to induce interferons alpha/beta even in the absence of transgene expression in human smmc-7721 cells, while it mediated transgene expression in bhk and l929 mammalian cells without an ensuing antiviral activity. |
| WOS关键词 | RECOMBINANT BACULOVIRUS VECTOR ; EFFICIENT GENE-TRANSFER ; ALPHA-INTERFERON ; INDUCTION ; EXPRESSION ; GLYCOPROTEINS ; PROTEINS |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| WOS类目 | Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000242641700009 |
| 出版者 | SCIENCE CHINA PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375285 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Chen Xinwen |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang Changyong,Song Jianhua,Hu Zhihong,et al. Group i but not group iinpv induces antiviral effects in mammalian cells[J]. Science in china series c-life sciences,2006,49(5):467-472. |
| APA | Liang Changyong,Song Jianhua,Hu Zhihong,&Chen Xinwen.(2006).Group i but not group iinpv induces antiviral effects in mammalian cells.Science in china series c-life sciences,49(5),467-472. |
| MLA | Liang Changyong,et al."Group i but not group iinpv induces antiviral effects in mammalian cells".Science in china series c-life sciences 49.5(2006):467-472. |
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来源：武汉病毒研究所
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