Two new pentacyclic triterpene saponins from the leaves of akebia trifoliata
文献类型：期刊论文
| 作者 | Xu, Qiao-Lin1; Wang, Jing2,3; Dong, Li-Mei2,4; Zhang, Qiang3,4; Luo, Bi3,4; Jia, Yong-Xia2,3; Wang, Hong-Feng1; Tan, Jian-Wen2,3 |
| 刊名 | Molecules
 |
| 出版日期 | 2016-07-01 |
| 卷号 | 21期号:7页码:9 |
| ISSN号 | 1420-3049 |
| 关键词 | Akebia trifoliata Triterpene saponins Alpha-glucosidase inhibitor Cytotoxicity |
| DOI | 10.3390/molecules21070962 |
| 通讯作者 | Tan, jian-wen(jwtan@scbg.ac.cn) |
| 英文摘要 | Two new pentacyclic triterpene saponins, named akebiaoside k (1) and akebiaoside n (2), were isolated from the leaves of akebia trifoliata, together with five known triterpenoids 3-7. they were all isolated from the leaves of a. trifoliata for the first time. their structures were established by spectral and chemical means. triterpenes 5 and 7 were found to show moderate in vitro cytotoxicity against human tumor a549, hela and hepg2 cell lines, with ic50 values ranging from 0.023 to 0.038 mm. triterpenes 5-7 were further revealed to show significant in vitro -glucosidase inhibitory activity with ic50 values from 0.040 to 0.220 mm, making them more potent than the reference compound acarbose (ic50 0.409 mm). meanwhile, no obvious inhibitory effects were observed for the isolated triterpene saponins 1-4 in both bioactivity assays. |
| WOS关键词 | PERICARPS ; GLYCOSIDES |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Organic |
| 语种 | 英语 |
| 出版者 | MDPI AG |
| WOS记录号 | WOS:000381509700143 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375297 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Tan, Jian-Wen |
| 作者单位 | 1.Guangdong Acad Forestry, Guangdong Prov Key Lab Biocontrol Forest Dis & Pe, Guangzhou 510520, Guangdong, Peoples R China 2.Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China 3.Chinese Acad Sci, Guangdong Prov Key Lab Appl Bot, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China 4.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Qiao-Lin,Wang, Jing,Dong, Li-Mei,et al. Two new pentacyclic triterpene saponins from the leaves of akebia trifoliata[J]. Molecules,2016,21(7):9. |
| APA | Xu, Qiao-Lin.,Wang, Jing.,Dong, Li-Mei.,Zhang, Qiang.,Luo, Bi.,...&Tan, Jian-Wen.(2016).Two new pentacyclic triterpene saponins from the leaves of akebia trifoliata.Molecules,21(7),9. |
| MLA | Xu, Qiao-Lin,et al."Two new pentacyclic triterpene saponins from the leaves of akebia trifoliata".Molecules 21.7(2016):9. |
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来源：中国科学院大学
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