Effects of (-)stepholidine in animal models for schizophrenia
文献类型：期刊论文
| 作者 | Ellenbroek, Bart A.; Zhang, Xue-xiang; Jin, Guo-zhang |
| 刊名 | Acta pharmacologica sinica
 |
| 出版日期 | 2006-09-01 |
| 卷号 | 27期号:9页码:1111-1118 |
| ISSN号 | 1671-4083 |
| 关键词 | Acoustic startle response Antipsychotics Apomorphine Dopamine d-1 receptor Dopamine d-2 receptor Mk801 Paw test Prepulse inhibition Clozapine Haloperidol |
| DOI | 10.1111/j.1745-7254.2006.00365.x |
| 通讯作者 | Ellenbroek, bart a.(a.ellenbroek@cns.umcn.nl) |
| 英文摘要 | Aim: (-)stepholidine (spd) is an active ingredient of the chinese herb stephania intermedia, which binds to the dopamine d-1 and d-2 like receptors. biochemical, electrophysiological and behavioural experiments have provided strong evidence that spd is both a d-1 and a d-2 antagonist, which could make spd a unique antipsychotic drug. the present study aimed to investigate the antipsychotic properties of spd in two animal models for schizophrenia. methods: the effects of spd, clozapine and haloperidol in increasing forelimb and hindlimb retraction time in the paw test and in reversing the apornorphine and mk801-induced disruption of prepulse inhibition was investigated. results: in the paw test, clozapine and spd increased the hindlimb retraction time, with only a marginal effect on the forelimb retraction time, whereas haloperidol potently increased both. in the prepulse inhibition paradigm, all three drugs reverse the apomorphine-induced disruption in prepulse inhibition, while none of the drugs could reverse the mk801 induced disruption. spd even slightly, but significantly, potentiated the effects of mk801. conclusion: the data show that spd showed antipsychotic-like effects in both the prepulse inhibition paradigm and in the paw test. moreover, the results of the paw test suggest that spd has an atypical character with a relatively small potency to induce extrapyramidal side effects. |
| WOS关键词 | PHENCYCLIDINE-INDUCED DISRUPTION ; ACOUSTIC STARTLE RESPONSE ; PREPULSE INHIBITION ; PAW TEST ; NEUROLEPTIC DRUGS ; DOPAMINE-RECEPTORS ; PREFRONTAL CORTEX ; ANTIPSYCHOTIC-DRUGS ; FIRING ACTIVITY ; WORKING-MEMORY |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | BLACKWELL PUBLISHING |
| WOS记录号 | WOS:000240554800002 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375332 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Ellenbroek, Bart A. |
| 作者单位 | 1.Univ Nijmegen, Mol Neurobiol Sect, Dept Cognit Neurosci, NL-6500 HB Nijmegen, Netherlands 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ellenbroek, Bart A.,Zhang, Xue-xiang,Jin, Guo-zhang. Effects of (-)stepholidine in animal models for schizophrenia[J]. Acta pharmacologica sinica,2006,27(9):1111-1118. |
| APA | Ellenbroek, Bart A.,Zhang, Xue-xiang,&Jin, Guo-zhang.(2006).Effects of (-)stepholidine in animal models for schizophrenia.Acta pharmacologica sinica,27(9),1111-1118. |
| MLA | Ellenbroek, Bart A.,et al."Effects of (-)stepholidine in animal models for schizophrenia".Acta pharmacologica sinica 27.9(2006):1111-1118. |
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来源：武汉病毒研究所
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