Ph and redox-operated nanovalve for size-selective cargo delivery on hollow mesoporous silica spheres
文献类型：期刊论文
| 作者 | Zhu, Xinyun; Wang, Cai-Qi |
| 刊名 | Journal of colloid and interface science
 |
| 出版日期 | 2016-10-15 |
| 卷号 | 480页码:39-48 |
| 关键词 | Hollow mesoporous silica spheres Dual-responsive Supramolecular nanovalve Cargo size-selective Drug delivery system |
| ISSN号 | 0021-9797 |
| DOI | 10.1016/j.jcis.2016.06.043 |
| 通讯作者 | Wang, cai-qi(wang-caiqi@ucas.ac.cn) |
| 英文摘要 | A ph and redox dual-responsive nanovalve with a long stalk was introduced on the surface of hollow mesoporous silica nanoparticles (hmss-s1) to achieve cargo size selectivity delivery. the responsive nanovalve was designed by constructing of a stalk/beta-cyclodextrins (cds) supramolecular complex, which is based on an acid-labile acetal group and the host-guest interactions between beta-cyclodextrins and ferrocenyl moiety (fc). with stimulation by different ph and h2o2, rhodamine 6g showed well-responsive behavior. on account of the long stalks of nanovalve, doxorubicin hydrochloride and 5-fluorouracil with different sized cargos are encapsulated in hmss-s1 to test its behavior of cargo size-selective delivery. moreover the hmss-s2 with a short stalk based on beta-cds/fc inclusion complex is synthesized to load small sized 5-fu drug as contrast experiment. compared with hmss-s2, hmss-s1 is compatible with larger drug molecules such as rhodamine 6g (r6g) and doxorubicin hydrochloride (dox), while small sized 5-fluorouracil (5-fu) is unable to be sealed by the nanovalve. dual responsiveness and drug size selectivity make mechanized hmss possess potential applications in drug delivery system. (c) 2016 elsevier inc. all rights reserved. |
| WOS关键词 | RESPONSIVE DRUG-DELIVERY ; CONTROLLED-RELEASE ; IN-VITRO ; INTRACELLULAR DELIVERY ; NANOPARTICLES ; ACID ; CYCLODEXTRIN ; MOLECULES ; CANCER ; PSEUDOROTAXANES |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Physical |
| 语种 | 英语 |
| WOS记录号 | WOS:000381244900005 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375336 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Cai-Qi |
| 作者单位 | Univ Chinese Acad Sci, Coll Chem & Chem Engn, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Xinyun,Wang, Cai-Qi. Ph and redox-operated nanovalve for size-selective cargo delivery on hollow mesoporous silica spheres[J]. Journal of colloid and interface science,2016,480:39-48. |
| APA | Zhu, Xinyun,&Wang, Cai-Qi.(2016).Ph and redox-operated nanovalve for size-selective cargo delivery on hollow mesoporous silica spheres.Journal of colloid and interface science,480,39-48. |
| MLA | Zhu, Xinyun,et al."Ph and redox-operated nanovalve for size-selective cargo delivery on hollow mesoporous silica spheres".Journal of colloid and interface science 480(2016):39-48. |
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来源：中国科学院大学
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