Mycobacterial whib6 differentially regulates esx-1 and the dos regulon to modulate granuloma formation and virulence in zebrafish
文献类型：期刊论文
| 作者 | Chen, Zhenkang1,4; Hu, Yangbo1; Cumming, Bridgette M.2; Lu, Pei1; Feng, Lipeng1; Deng, Jiaoyu1; Steyn, Adrie J. C.2,3; Chen, Shiyun1 |
| 刊名 | Cell reports
 |
| 出版日期 | 2016-08-30 |
| 卷号 | 16期号:9页码:2512-2524 |
| ISSN号 | 2211-1247 |
| DOI | 10.1016/j.celrep.2016.07.080 |
| 通讯作者 | Chen, shiyun(sychen@wh.iov.cn) |
| 英文摘要 | During the course of infection, mycobacterium tuberculosis (mtb) is exposed to diverse redox stresses that trigger metabolic and physiological changes. how these stressors are sensed and relayed to the mtb transcriptional apparatus remains unclear. here, we provide evidence that whib6 differentially regulates the esx-1 and dosr regulons through its fe-s cluster. when challenged with no, whib6 continually activates expression of the dosr regulons but regulates esx-1 expression through initial activation followed by gradual inhibition. comparative transcriptomic analysis of the holo-and reduced apo-whib6 complemented strains confirms these results and also reveals that whib6 controls aerobic and anaerobic metabolism, cell division, and virulence. using the mycobacterium marinum zebrafish infection model, we find that holo-and apo-whib6 modulate levels of mycobacterial infection, granuloma formation, and dissemination. these findings provide fresh insight into the role of whib6 in mycobacterial infection, dissemination, and disease development. |
| WOS关键词 | IRON-SULFUR CLUSTER ; NITRIC-OXIDE ; TUBERCULOSIS H37RV ; STRESS CONDITIONS ; GENE-EXPRESSION ; CARBON-MONOXIDE ; BOVIS BCG ; INFECTION ; DORMANCY ; SECRETION |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000382311300021 |
| 出版者 | CELL PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375337 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, Shiyun |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, Ctr Emerging Infect Dis, Key Lab Special Pathogens & Biosafety, Wuhan 430071, Peoples R China 2.KwaZulu Natal Res Inst TB & HIV, ZA-4001 Durban, South Africa 3.Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA 4.Univ Chinese Acad Sci, Beijing 10086, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Zhenkang,Hu, Yangbo,Cumming, Bridgette M.,et al. Mycobacterial whib6 differentially regulates esx-1 and the dos regulon to modulate granuloma formation and virulence in zebrafish[J]. Cell reports,2016,16(9):2512-2524. |
| APA | Chen, Zhenkang.,Hu, Yangbo.,Cumming, Bridgette M..,Lu, Pei.,Feng, Lipeng.,...&Chen, Shiyun.(2016).Mycobacterial whib6 differentially regulates esx-1 and the dos regulon to modulate granuloma formation and virulence in zebrafish.Cell reports,16(9),2512-2524. |
| MLA | Chen, Zhenkang,et al."Mycobacterial whib6 differentially regulates esx-1 and the dos regulon to modulate granuloma formation and virulence in zebrafish".Cell reports 16.9(2016):2512-2524. |
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来源：中国科学院大学
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