Integrating a dna strand displacement reaction with a whispering gallery mode sensor for label-free mercury (ii) ion detection
文献类型：期刊论文
| 作者 | Wu, Fengchi1,2,3; Wu, Yuqiang3; Niu, Zhongwei1; Vollmer, Frank3,4 |
| 刊名 | Sensors
 |
| 出版日期 | 2016-08-01 |
| 卷号 | 16期号:8页码:10 |
| 关键词 | Whispering gallery mode Dna strand displacement Mercury (ii) ions detection Biosensing Label-free detection Optical microcavity Dna nanotechnology |
| ISSN号 | 1424-8220 |
| DOI | 10.3390/s16081197 |
| 通讯作者 | Vollmer, frank(frank.vollmer@mpl.mpg.de) |
| 英文摘要 | Mercury is an extremely toxic chemical pollutant of our environment. it has attracted the world's attention due to its high mobility and the ease with which it accumulates in organisms. sensitive devices and methods specific for detecting mercury ions are, hence, in great need. here, we have integrated a dna strand displacement reaction with a whispering gallery mode (wgm) sensor for demonstrating the detection of hg2+ ions. our approach relies on the displacement of a dna hairpin structure, which forms after the binding of mercury ions to an aptamer dna sequence. the strand displacement reaction of the dna aptamer provides highly specific and quantitative means for determining the mercury ion concentration on a label-free wgm sensor platform. our approach also shows the possibility for manipulating the kinetics of a strand displacement reaction with specific ionic species. |
| WOS关键词 | GOLD NANOPARTICLES ; FREE MICROCAVITY ; HG2+ ; PROTEIN ; FLUORESCENT ; RESONATORS ; BIOSENSOR ; APTAMER ; CATION ; SHIFT |
| WOS研究方向 | Chemistry ; Electrochemistry ; Instruments & Instrumentation |
| WOS类目 | Chemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation |
| 语种 | 英语 |
| WOS记录号 | WOS:000382323200185 |
| 出版者 | MDPI AG |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375353 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Vollmer, Frank |
| 作者单位 | 1.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100080, Peoples R China 3.Max Planck Inst Sci Light, Lab Nanophoton & Biosensing, D-91058 Erlangen, Germany 4.Harvard Med Sch, Brigham & Womens Hosp, Div Biomed Engn, Boston, MA 02115 USA |
| 推荐引用方式 GB/T 7714 | Wu, Fengchi,Wu, Yuqiang,Niu, Zhongwei,et al. Integrating a dna strand displacement reaction with a whispering gallery mode sensor for label-free mercury (ii) ion detection[J]. Sensors,2016,16(8):10. |
| APA | Wu, Fengchi,Wu, Yuqiang,Niu, Zhongwei,&Vollmer, Frank.(2016).Integrating a dna strand displacement reaction with a whispering gallery mode sensor for label-free mercury (ii) ion detection.Sensors,16(8),10. |
| MLA | Wu, Fengchi,et al."Integrating a dna strand displacement reaction with a whispering gallery mode sensor for label-free mercury (ii) ion detection".Sensors 16.8(2016):10. |
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来源：中国科学院大学
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