Hybrid of gold nanostar and indocyanine green for targeted imaging-guided diagnosis and phototherapy using low-density laser irradiation
文献类型：期刊论文
| 作者 | Du, Baoji1,2; Gu, Xiaoxiao1; Zhao, Wenjing1; Liu, Zuojia1; Li, Dan1; Wang, Erkang1; Wang, Jin1,3,4 |
| 刊名 | Journal of materials chemistry b
 |
| 出版日期 | 2016 |
| 卷号 | 4期号:35页码:5842-5849 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c6tb01375a |
| 通讯作者 | Li, dan(lidan@ciac.ac.cn) ; Wang, erkang(ekwang@ciac.ac.cn) ; Wang, jin(jin.wang.1@stonybrook.edu) |
| 英文摘要 | Phototherapy is widely studied with the development of photothermal nanomaterials. however, the laser power density for reaching effective phototherapy is still high and dangerous for normal tissues. in this research, based on multi-functional polydopamine, we proposed a general strategy to design diverse core-shell nanoparticles with different surface charges, and synthesized a targeted nanoplatform, auns@pda-pei-fa (app), by coupling gold nanostar (auns) with polyethylenimine-folate (pei-fa). owing to the electrostatic interaction, the as-prepared app can anchor a negatively-charged photosensitizer, indocyanine green (icg), for photothermal and photodynamic synergistic cancer therapy. the app-icg is able to realize the targeted phototherapy for tumor cells even at the low power laser density of 0.33 w cm(-2) both in vitro and in vivo. furthermore, app-icg is not only a treatment nanoplatform but also a diagnosis agent. the integrative diagnosis results can be acquired by dual imaging technologies: the near-infrared fluorescence images and the photothermal images acquired by an in vivo imaging system and a thermal imaging camera, respectively. this new nanoplatform is a good diagnosis and treatment system and has the potential for further theranostics application. |
| WOS关键词 | REDUCED GRAPHENE OXIDE ; IN-VIVO ; CANCER-THERAPY ; DRUG-DELIVERY ; PHOTODYNAMIC THERAPY ; SYNERGISTIC THERAPY ; NANOPARTICLES ; CELLS ; NANOSHEETS ; NANORODS |
| WOS研究方向 | Materials Science |
| WOS类目 | Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000382763900010 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375363 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Li, Dan; Wang, Erkang; Wang, Jin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Jilin Univ, Coll Phys, Changchun 130012, Jilin, Peoples R China 4.SUNY Stony Brook, Dept Chem & Phys, Stony Brook, NY 11794 USA |
| 推荐引用方式 GB/T 7714 | Du, Baoji,Gu, Xiaoxiao,Zhao, Wenjing,et al. Hybrid of gold nanostar and indocyanine green for targeted imaging-guided diagnosis and phototherapy using low-density laser irradiation[J]. Journal of materials chemistry b,2016,4(35):5842-5849. |
| APA | Du, Baoji.,Gu, Xiaoxiao.,Zhao, Wenjing.,Liu, Zuojia.,Li, Dan.,...&Wang, Jin.(2016).Hybrid of gold nanostar and indocyanine green for targeted imaging-guided diagnosis and phototherapy using low-density laser irradiation.Journal of materials chemistry b,4(35),5842-5849. |
| MLA | Du, Baoji,et al."Hybrid of gold nanostar and indocyanine green for targeted imaging-guided diagnosis and phototherapy using low-density laser irradiation".Journal of materials chemistry b 4.35(2016):5842-5849. |
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来源：中国科学院大学
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