Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via ap-1 and ets1
文献类型：期刊论文
| 作者 | Ye, Feng-Chun; Blackbourn, David J.; Mengel, Michael; Xie, Jian-Ping; Qian, Li-Wu; Greene, Whitney; Yeh, I-Tien; Graham, David; Gao, Shou-Jiang |
| 刊名 | Journal of virology
 |
| 出版日期 | 2007-04-01 |
| 卷号 | 81期号:8页码:3980-3991 |
| ISSN号 | 0022-538X |
| DOI | 10.1128/jvi.02089-06 |
| 通讯作者 | Gao, shou-jiang(gaos@uthscsa.edu) |
| 英文摘要 | Infection by kaposi's sarcoma-associated herpesvirus (kshv) is required for the development of kaposi's sarcoma (ks), a highly inflammatory angiogenic tumor of endothelial cells commonly found in untreated aids patients. angiopoietin 2 (ang-2) modulates the vasculature during inflammation and angiogenesis, but the mechanism by which kshv regulates ang-2 expression has not been investigated. here, we show that kshv infection of primary human umbilical vein endothelial cells induced the expression and release of ang-2, which in turn was required for kshv-induced paracrine-dependent angiogenesis in vivo. ang-2 was strongly expressed in small vessels and spindle tumor cells in ks tumors. mechanistically, kshv activated the ang-2 promoter via ap-1 and ets1 transcriptional factors, which were mediated by erk, jnk, and p38 mitogen-activated protein kinase (mapk) pathways. our findings demonstrate the importance of ang-2 in ks angiogenesis and define a novel role for ap-1 and mapk pathways in regulating angiogenesis. this study also illustrates a distinct mechanism by which a tumor virus modulates vasculature to promote tumorigenesis and exemplifies the convergence of oncogenesis and angiogenesis pathways in tumor development. |
| WOS关键词 | MICROVASCULAR ENDOTHELIAL-CELLS ; ACTIVATED PROTEIN-KINASE ; NF-KAPPA-B ; TYRAMINE AMPLIFICATION TECHNIQUE ; PRIMARY-EFFUSION LYMPHOMA ; GROWTH-FACTOR EXPRESSION ; TUMOR ANGIOGENESIS ; PRIMARY INFECTION ; GENE-EXPRESSION ; IN-VIVO |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000245692900030 |
| 出版者 | AMER SOC MICROBIOLOGY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375404 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Gao, Shou-Jiang |
| 作者单位 | 1.Univ Texas, Hlth Sci Ctr, Tumor Virol Program, Childrens Canc Res Inst, San Antonio, TX 78229 USA 2.Univ Texas, Hlth Sci Ctr, Dept Pediat, San Antonio, TX 78229 USA 3.Univ Texas, Hlth Sci Ctr, Dept Microbiol & Immunol, San Antonio, TX 78229 USA 4.Univ Texas, Hlth Sci Ctr, Dept Mol Med, San Antonio, TX 78229 USA 5.Univ Texas, Hlth Sci Ctr, Dept Pathol, San Antonio, TX 78229 USA 6.Univ Texas, Hlth Sci Ctr, San Antonio Canc Inst, San Antonio, TX 78229 USA 7.Chinese Acad Sci, Wuhan Inst Virol, Tumor Virol Grp, Wuhan, Peoples R China 8.Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham, W Midlands, England 9.Med Hochsch Hannover, Inst Pathol, Hannover, Germany |
| 推荐引用方式 GB/T 7714 | Ye, Feng-Chun,Blackbourn, David J.,Mengel, Michael,et al. Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via ap-1 and ets1[J]. Journal of virology,2007,81(8):3980-3991. |
| APA | Ye, Feng-Chun.,Blackbourn, David J..,Mengel, Michael.,Xie, Jian-Ping.,Qian, Li-Wu.,...&Gao, Shou-Jiang.(2007).Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via ap-1 and ets1.Journal of virology,81(8),3980-3991. |
| MLA | Ye, Feng-Chun,et al."Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via ap-1 and ets1".Journal of virology 81.8(2007):3980-3991. |
入库方式： iSwitch采集
来源：武汉病毒研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。