Evidence of the recombinant origin of a bat severe acute respiratory syndrome (sars)-like coronavirus and its implications on the direct ancestor of sars coronavirus
文献类型：期刊论文
| 作者 | Hon, Chung-Chau1; Lam, Tsan-Yuk1; Shi, Zheng-Li2; Drummond, Alexei J.3; Yip, Chi-Wai1; Zeng, Fanya1; Lam, Pui-Yi1; Leung, Frederick Chi-Ching1 |
| 刊名 | Journal of virology
 |
| 出版日期 | 2008-02-01 |
| 卷号 | 82期号:4页码:1819-1826 |
| ISSN号 | 0022-538X |
| DOI | 10.1128/jvi.01926-07 |
| 通讯作者 | Leung, frederick chi-ching(fcleung@hkucc.hku.hk) |
| 英文摘要 | Bats have been identified as the natural reservoir of severe acute respiratory syndrome (sars)-like and sars coronaviruses (slcov and scov). however, previous studies suggested that none of the currently sampled bat slcovs is the descendant of the direct ancestor of scov, based on their relatively distant phylogenetic relationship. in this study, evidence of the recombinant origin of the genome of a bat slcov is demonstrated. we identified a potential recombination breakpoint immediately after the consensus intergenic sequence between open reading frame 1 and the s coding region, suggesting the replication intermediates may participate in the recombination event, as previously speculated for other covs. phylogenetic analysis of its parental regions suggests the presence of an uncharacterized slcov lineage that is phylogenetically closer to scovs than any of the currently sampled bat slcovs. using various bayesian molecular-clock models, interspecies transfer of this slcov lineage from bats to the amplifying host (e.g., civets) was estimated to have happened a median of 4.08 years before the sars outbreak. based on this relatively short window period, we speculate that this uncharacterized slcov lineage may contain the direct ancestor of scov. this study sheds light on the possible host bat species of the direct ancestor of scov, providing valuable information on the scope and focus of surveillance for the origin of scov. |
| WOS关键词 | INFECTIOUS-BRONCHITIS VIRUS ; MOUSE HEPATITIS-VIRUS ; MOLECULAR EVOLUTION ; RNA RECOMBINATION ; PHYLOGENETIC ANALYSIS ; MURINE CORONAVIRUSES ; MAXIMUM-LIKELIHOOD ; FELINE CORONAVIRUS ; GENETIC DIVERSITY ; HORSESHOE BATS |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| 出版者 | AMER SOC MICROBIOLOGY |
| WOS记录号 | WOS:000252909300018 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375435 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Leung, Frederick Chi-Ching |
| 作者单位 | 1.Univ Hong Kong, Sch Biol Sci, Hong Kong, Hong Kong, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Hubei, Peoples R China 3.Univ Auckland, Bioinformat Inst, Auckland 1, New Zealand |
| 推荐引用方式 GB/T 7714 | Hon, Chung-Chau,Lam, Tsan-Yuk,Shi, Zheng-Li,et al. Evidence of the recombinant origin of a bat severe acute respiratory syndrome (sars)-like coronavirus and its implications on the direct ancestor of sars coronavirus[J]. Journal of virology,2008,82(4):1819-1826. |
| APA | Hon, Chung-Chau.,Lam, Tsan-Yuk.,Shi, Zheng-Li.,Drummond, Alexei J..,Yip, Chi-Wai.,...&Leung, Frederick Chi-Ching.(2008).Evidence of the recombinant origin of a bat severe acute respiratory syndrome (sars)-like coronavirus and its implications on the direct ancestor of sars coronavirus.Journal of virology,82(4),1819-1826. |
| MLA | Hon, Chung-Chau,et al."Evidence of the recombinant origin of a bat severe acute respiratory syndrome (sars)-like coronavirus and its implications on the direct ancestor of sars coronavirus".Journal of virology 82.4(2008):1819-1826. |
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来源：武汉病毒研究所
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