Protection abilities of influenza b virus dna vaccines expressing hemagglutinin, neuraminidase, or both in mice
文献类型：期刊论文
| 作者 | Fang, F.1; Cai, X. Q.1; Chang, H. Y.1; Wang, H. D.1; Yang, Z. D.3; Chen, Z.1,2,3 |
| 刊名 | Acta virologica
 |
| 出版日期 | 2008 |
| 卷号 | 52期号:2页码:107-112 |
| 关键词 | Dna vaccine Influenza b virus Hemagglutinin Neuraminidase |
| ISSN号 | 0001-723X |
| 通讯作者 | Fang, f.(fangfangc@263.net) |
| 英文摘要 | Every year, a vaccination against influenza b virus (ibv) is essential due to an antigenic variation. developemnt of an efficient and convenient vaccine is important for the prevention of viral infection. this study reports examination of the protective immunity in mice evoked by a single inovulation of plasmid dna expressing hemagglutinin (ha dna) or neuraminidase (na dna) of ibv. the ha dna or na dna was injected intramuscularly into balb/c mice separately or as a mixture. the injection of plasmid was followed by an electroporation close to the site of puncture. four weeks later, the immunized mice were challenged with a lethal dose of ibv. the protective abilities of dna vaccines were evaluated by the detection of ' specific antibodies in serum, survival rate, virus titer in lungs, and change of body weight. we found that a single dose of ha dna or na dna induced the formation of specific antibodiess and conferred effective protection against the lethal challenge of ibv. however , the combined vaccine ha dna and na dna enhanced the protective ability of immunized mice. the obtained result suggested that immunization with single dose of ha dna. na dna or with combination of both could be an efficient method for preventing ibv infection. |
| WOS关键词 | ANTIGENIC-COMPETITION ; ENHANCED PROTECTION ; PLASMID DNAS ; IMMUNIZATION ; INFECTION ; REASSORTMENT ; VACCINATION ; CHALLENGE ; PROTEIN ; ELECTROPORATION |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000260060900004 |
| 出版者 | AEPRESS SRO |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375465 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Fang, F. |
| 作者单位 | 1.Hunan Normal Univ, Coll Life Sci, Changsha 410081, Hunan, Peoples R China 2.Chinese Acad Sci, Natl Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Hubei, Peoples R China 3.Shanghai Inst Biol Prod, Shanghai 200052, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, F.,Cai, X. Q.,Chang, H. Y.,et al. Protection abilities of influenza b virus dna vaccines expressing hemagglutinin, neuraminidase, or both in mice[J]. Acta virologica,2008,52(2):107-112. |
| APA | Fang, F.,Cai, X. Q.,Chang, H. Y.,Wang, H. D.,Yang, Z. D.,&Chen, Z..(2008).Protection abilities of influenza b virus dna vaccines expressing hemagglutinin, neuraminidase, or both in mice.Acta virologica,52(2),107-112. |
| MLA | Fang, F.,et al."Protection abilities of influenza b virus dna vaccines expressing hemagglutinin, neuraminidase, or both in mice".Acta virologica 52.2(2008):107-112. |
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来源：武汉病毒研究所
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