Reactivation of kaposi's sarcoma-associated herpesvirus from latency requires mek/erk, jnk and p38 multiple mitogen-activated protein kinase pathways
文献类型：期刊论文
| 作者 | Xie, Jianping1,2; Ajibade, Adetola Olalekan1,3; Ye, Fengchun1,2; Kuhne, Kurt1,3; Gao, Shou-Jiang1,2,3,4,5,6,7 |
| 刊名 | Virology
 |
| 出版日期 | 2008-02-05 |
| 卷号 | 371期号:1页码:139-154 |
| 关键词 | Kaposi's sarcoma Kshv Reactivation Mapk pathways Ap-1 Rta Tpa |
| ISSN号 | 0042-6822 |
| DOI | 10.1016/j.virol.2007.09.040 |
| 通讯作者 | Gao, shou-jiang(gaos@uthscsa.edu) |
| 英文摘要 | Lytic replication of kaposi's sarcoma-associated herpesvirus (kshv) promotes the progression of kaposi's sarcoma (ks), a dominant malignancy in patients with aids. while 12-o-tetradecanoyl-phorbol-13-acetate (tpa)-induced kshv reactivation from latency is mediated by the protein kinase c delta and mek/erk mitogen-activated protein kinase (mapk) pathways, we have recently shown that the mek/erk, jnk and p38 mapk pathways modulate kshv lytic replication during productive primary infection of human umbilical vein endothelial cells [pan, h., xie, j., ye, f., gao, s.j., 2006. modulation of kaposi's sarcoma-associated herpesvirus infection and replication by mek/erk, jnk, and p38 multiple mitogen-activated protein kinase pathways during primary infection. j. virol. 80 (11), 5371-5382]. here, we report that, besides the mek/erk pathway, the jnk and p38 mapk pathways also mediate tpa-induced kshv reactivation from latency. the mek/erk, jnk and p38 mapk pathways were constitutively activated in latent kshv-infected bcbl-1 cells. tpa treatment enhanced the levels of activated erk and p38 but not those of activated jnk. inhibitors of all three mapk pathways reduced tpa-induced production of kshv infectious virions in bcbl-1 cells in a dose-dependent fashion. the inhibitors blocked kshv lytic replication at the early stage(s) of reactivation, and reduced the expression of viral lytic genes including rta, a key immediate-early transactivator of viral lytic replication. activation of mapk pathways was necessary and sufficient for activating the promoter of rta. furthermore, we showed that the activation of rta promoter by mapk pathways was mediated by their downstream target ap-1. together, these findings suggest that mapk pathways might have general roles in regulating the life cycle of kshv by mediating both viral infection and switch from viral latency to lytic replication. (c) 2007 elsevier inc. all rights reserved. |
| WOS关键词 | NF-KAPPA-B ; NOTCH SIGNALING PATHWAY ; NUCLEAR ANTIGEN ; LYTIC REPLICATION ; PRIMARY INFECTION ; GENE-EXPRESSION ; C-JUN ; ENDOTHELIAL-CELLS ; INFLAMMATORY CYTOKINES ; RESPONSE ELEMENTS |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000252725700014 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375475 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Gao, Shou-Jiang |
| 作者单位 | 1.Univ Texas Hlth Sci Ctr San Antonio, Tumor Virol Program, Greehey Childrens Canc Res Inst, San Antonio, TX 78229 USA 2.Univ Texas Hlth Sci Ctr San Antonio, Dept Pediat, San Antonio, TX 78229 USA 3.Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA 4.Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA 5.Univ Texas Hlth Sci Ctr San Antonio, Dept Mol Med, San Antonio, TX 78229 USA 6.Univ Texas Hlth Sci Ctr San Antonio, San Antonio Canc Inst, San Antonio, TX 78229 USA 7.Chinese Acad Sci, Wuhan Inst Virol, Tumor Virol Grp, Wuhan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Jianping,Ajibade, Adetola Olalekan,Ye, Fengchun,et al. Reactivation of kaposi's sarcoma-associated herpesvirus from latency requires mek/erk, jnk and p38 multiple mitogen-activated protein kinase pathways[J]. Virology,2008,371(1):139-154. |
| APA | Xie, Jianping,Ajibade, Adetola Olalekan,Ye, Fengchun,Kuhne, Kurt,&Gao, Shou-Jiang.(2008).Reactivation of kaposi's sarcoma-associated herpesvirus from latency requires mek/erk, jnk and p38 multiple mitogen-activated protein kinase pathways.Virology,371(1),139-154. |
| MLA | Xie, Jianping,et al."Reactivation of kaposi's sarcoma-associated herpesvirus from latency requires mek/erk, jnk and p38 multiple mitogen-activated protein kinase pathways".Virology 371.1(2008):139-154. |
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来源：武汉病毒研究所
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