Multiple amino acid substitutions are involved in the adaptation of h9n2 avian influenza virus to mice
文献类型：期刊论文
| 作者 | Wu, Rui1,2,3; Zhang, Hongbo3; Yang, Keli1; Liang, Wangwang1; Xiong, Zhongliang1; Liu, Zewen1; Yang, Xuehai1; Shao, Huabin1; Zheng, Xinmin1; Chen, Mingxin1 |
| 刊名 | Veterinary microbiology
 |
| 出版日期 | 2009-07-02 |
| 卷号 | 138期号:1-2页码:85-91 |
| 关键词 | Avian influenza virus H9n2 subtype Mouse Adaptation Pathogenicity |
| ISSN号 | 0378-1135 |
| DOI | 10.1016/j.vetmic.2009.03.010 |
| 通讯作者 | Xu, diping(xudiping2007@126.com) |
| 英文摘要 | To explore adaptation of avian influenza virus to mice we previously performed serial lung-to-lung passages of the influenza a/chicken/jiangsu/7/2002 (h9n2) strain, resulting in the isolation of a variant influenza strain lethal for mice. we now report that virulence correlates with improved growth characteristics on mammalian cells and extended tissue tropism in vivo. sequencing of the complete genomes of the wild-type and mouse-adapted viruses revealed 25 amino acid substitutions. some were found to reiterate known substitutions in human and swine h9n2 influenza isolates. functions affected include nuclear localization signals and sites of protein and rna interaction, while others are known determinants of pathogenicity and host specificity such as the viral polymerase pb2 e627k substitution. these observations suggest that enhanced growth characteristics and modified cell tropism may contribute to increased virulence in mice. we conclude that multiple amino acid substitutions are likely to be involved in the adaptation of h9n2 avian influenza virus to mice. (c) 2009 elsevier b.v. all rights reserved. |
| WOS关键词 | A VIRUSES ; HONG-KONG ; INCREASED VIRULENCE ; VIRAL POLYMERASE ; MOLECULAR-BASIS ; HUMAN INFECTION ; CELL TROPISM ; NS1 PROTEIN ; PB2 PROTEIN ; HOST-RANGE |
| WOS研究方向 | Microbiology ; Veterinary Sciences |
| WOS类目 | Microbiology ; Veterinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000267778100011 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375551 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Xu, Diping |
| 作者单位 | 1.Hubei Acad Agr Sci, Inst Anim Husb & Vet Sci, Wuhan 430064, Hubei, Peoples R China 2.Hubei Key Lab Anim Embryo Engn & Mol Breeding, Wuhan 430064, Hubei, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Rui,Zhang, Hongbo,Yang, Keli,et al. Multiple amino acid substitutions are involved in the adaptation of h9n2 avian influenza virus to mice[J]. Veterinary microbiology,2009,138(1-2):85-91. |
| APA | Wu, Rui.,Zhang, Hongbo.,Yang, Keli.,Liang, Wangwang.,Xiong, Zhongliang.,...&Xu, Diping.(2009).Multiple amino acid substitutions are involved in the adaptation of h9n2 avian influenza virus to mice.Veterinary microbiology,138(1-2),85-91. |
| MLA | Wu, Rui,et al."Multiple amino acid substitutions are involved in the adaptation of h9n2 avian influenza virus to mice".Veterinary microbiology 138.1-2(2009):85-91. |
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来源：武汉病毒研究所
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