Seroprevalence of kaposi's sarcoma-associated herpesvirus and risk factors in xinjiang, china
文献类型：期刊论文
| 作者 | Fu, Bishi3; Sun, Feng4; Li, Baolin3; Yang, Lei5; Zeng, Yan5; Sun, Xiulian3; Xu, Fanhong6; Rayner, Simon3; Guadalupe, Moraima1,2; Gao, Shou-Jiang1,2,3 |
| 刊名 | Journal of medical virology
 |
| 出版日期 | 2009-08-01 |
| 卷号 | 81期号:8页码:1422-1431 |
| 关键词 | Kshv/hhv8 Kaposi's sarcoma Seroprevalence Risk factors Genotype Xinjiang China |
| ISSN号 | 0146-6615 |
| DOI | 10.1002/jmv.21550 |
| 通讯作者 | Gao, shou-jiang(gaos@uthscsa.edu) |
| 英文摘要 | Xinjiang, china is an endemic area for kaposi's sarcoma (ks) but the seroprevalence of kaposi's sarcoma-associated herpesvirus (kshv) and risk factors remain undefined. in this study, antibodies to one kshv latent protein (orf73) and two kshv lytic proteins (orf65 and orf-k8.1) were examined in 2,228 subjects from the general population and 37 subjects infected with hiv-1 in xinjiang, and 560 subjects from the general population in hubei, a low ks incidence region. the serostatus of a serum sample was defined based on positive results in any one of the three serologic assays. the seroprevalence of kshv in the general population was higher in xinjiang than in hubei (19.2% vs. 9.5%; odds ratios [or], 2.28; 95% confidence interval [ci], 1.68-3.08; p < 0.001). among the ethnic groups in xinjiang, 68 (15.8%) han, 182 (20.7%) uygur, 140 (19.9%) hazakh, 9 (33.3%) xibo, and 29 (16.8%) hui were kshv-seropositive, respectively. compared to the han, the latter groups had an increase in the risk of kshv of 62.2%, 63.8%, 180.1%, and 30.2% (p = 0.003, 0.004, 0.018, and 0.286, respectively). subjects aged <20, 20-50, and >50 had a seroprevalence of kshv of 11.8%, 17.9%, and 24.6%, respectively. compared to subjects aged <20, the latter groups had an increase in the risk of kshv of 63.3% and 144.5% (p = 0.009 and <0.001, respectively). subjects infected with hiv-1 in xinjiang had a seroprevalence of kshv of 43.2%, and a 220% increase in the risk of kshv compared to the general population (p < 0.001). similar results were obtained when the seroprevalence of kshv was analyzed with any single or two of the three serologic assays alone. genotyping identified three unique sequences clustered in the a clade. this study indicates that xinjiang has a high seroprevalence of kshv. geographic location, ethnicity, age and hiv-1 infection are risk factors. serologic and genotyping results suggest the introduction of kshv into xinjiang by specific ethnic groups. j. med. virol. 81:1422-1431, 2009. (c) 2009 wiley-liss, inc. |
| WOS关键词 | HUMAN-IMMUNODEFICIENCY-VIRUS ; DNA-SEQUENCES ; HUMAN-HERPESVIRUS-8 INFECTION ; ANTIBODIES ; PREVALENCE ; AFRICA ; HHV-8 ; TRANSMISSION ; ANTIGENS ; ASSAYS |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000267611000014 |
| 出版者 | WILEY-LISS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375587 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Gao, Shou-Jiang |
| 作者单位 | 1.Univ Texas Hlth Sci Ctr San Antonio, Tumor Virol Program, Greehey Childrens Canc Res Inst, San Antonio, TX 78229 USA 2.Univ Texas Hlth Sci Ctr San Antonio, Dept Pediat, San Antonio, TX 78229 USA 3.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China 4.Ctr Dis Control & Prevent Yili Hazakh Autonomous, Yining, Peoples R China 5.Shihezi Univ, Lab Xinjiang Endem & Ethn Dis, Shihezi, Peoples R China 6.Shanghai Inst Biol Prod, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Bishi,Sun, Feng,Li, Baolin,et al. Seroprevalence of kaposi's sarcoma-associated herpesvirus and risk factors in xinjiang, china[J]. Journal of medical virology,2009,81(8):1422-1431. |
| APA | Fu, Bishi.,Sun, Feng.,Li, Baolin.,Yang, Lei.,Zeng, Yan.,...&Wang, Linding.(2009).Seroprevalence of kaposi's sarcoma-associated herpesvirus and risk factors in xinjiang, china.Journal of medical virology,81(8),1422-1431. |
| MLA | Fu, Bishi,et al."Seroprevalence of kaposi's sarcoma-associated herpesvirus and risk factors in xinjiang, china".Journal of medical virology 81.8(2009):1422-1431. |
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来源：武汉病毒研究所
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