Functional analysis of the autographa californica nucleopolyhedrovirus iap1 and iap2
文献类型：期刊论文
| 作者 | Zeng XianDong1,2; Nan Fang1; Liang ChangYong1; Song JianHua1; Wang Qian1; Vlak, Just M.3; Chen XinWen1 |
| 刊名 | Science in china series c-life sciences
 |
| 出版日期 | 2009-08-01 |
| 卷号 | 52期号:8页码:761-770 |
| 关键词 | Iap1 Iap2 Acmnpv Hearnpv |
| ISSN号 | 1006-9305 |
| DOI | 10.1007/s11427-009-0105-5 |
| 通讯作者 | Chen xinwen(chenxw@pentium.whiov.ac.cn) |
| 英文摘要 | The autographa californica nucleopolyhedrovirus (acmnpv) contains three apoptosis suppressor genes: p35, iap1 and iap2. acmnpv p35 functions as a pancaspase inhibitor, but the function of iap1 and iap2 has not been entirely resolved. in this paper, we analyze the function of iap1 and iap2 in detail. acmnpv with p35-deletion inhibited the apoptosis of bti-tn-5b1-4 (tn-hi5) cells induced by a helicoverpa armigera single nucleocapsid npv (hearnpv) infection and rescued the replication of hearnpv and bv production in these cells. transient-expression experiments indicated that both iap1 and iap2 suppress apoptosis of tn-hi5 cells during hearnpv infection. recombinant hearnpvs expressing acmnpv iap1, iap2 and p35, respectively, not only prevented apoptosis but also allowed hearnpv to replicate in tn-hi5 cells. however, the iap1, iap2 and p35 genes when expressed in hearnpv were unable to rescue bv production. these results indicate that both acmnpv iap1 and iap2 function independently as apoptosis inhibitors of and are potential host range factors. |
| WOS关键词 | SINGLE-NUCLEOCAPSID NUCLEOPOLYHEDROVIRUS ; NUCLEAR POLYHEDROSIS-VIRUS ; CELL-DEATH ; HOST-RANGE ; IN-VIVO ; MULTICAPSID NUCLEOPOLYHEDROVIRUS ; APOPTOSIS PROTEINS ; BACULOVIRUS GENE ; BOMBYX-MORI ; INHIBITOR |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| WOS类目 | Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000269536400010 |
| 出版者 | SCIENCE PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375596 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Chen XinWen |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Wageningen Univ, Virol Lab, Wageningen, Netherlands |
| 推荐引用方式 GB/T 7714 | Zeng XianDong,Nan Fang,Liang ChangYong,et al. Functional analysis of the autographa californica nucleopolyhedrovirus iap1 and iap2[J]. Science in china series c-life sciences,2009,52(8):761-770. |
| APA | Zeng XianDong.,Nan Fang.,Liang ChangYong.,Song JianHua.,Wang Qian.,...&Chen XinWen.(2009).Functional analysis of the autographa californica nucleopolyhedrovirus iap1 and iap2.Science in china series c-life sciences,52(8),761-770. |
| MLA | Zeng XianDong,et al."Functional analysis of the autographa californica nucleopolyhedrovirus iap1 and iap2".Science in china series c-life sciences 52.8(2009):761-770. |
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来源：武汉病毒研究所
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