Comparative proteomic analysis to discover potential therapeutic targets in human multiple myeloma
文献类型：期刊论文
| 作者 | Xiao, Chuan-Le1; Zhang, Zhi-Ping2; Xiong, Sheng1; Lu, Chun-Hua1; Wei, Hong-Ping2; Zeng, Hui-Lan3; Liu, Zhi4; Zhang, Xian-En2; Ge, Feng1 |
| 刊名 | Proteomics clinical applications
 |
| 出版日期 | 2009-11-01 |
| 卷号 | 3期号:11页码:1348-1360 |
| 关键词 | Annexin a1 Multiple myeloma Plasma cell |
| ISSN号 | 1862-8346 |
| DOI | 10.1002/prca.200900068 |
| 通讯作者 | Ge, feng(tgfeng@jnu.edu.cn) |
| 英文摘要 | To clarify the molecular mechanisms that participate in the formation of multiple myeloma (mm) and to detect any tumor-related biomarkers, we performed proteomic analysis of cellular protein extracts from mm cells and normal plasma cells. plasma cells from nine patients with newly diagnosed mm and nine healthy donors were purified by using anti-cd138 based immunomagnetic bead-positive selection. the protein profiles of purified mm and normal plasma cells were compared using 2-de. we identified a total of 43 differentially expressed proteins, and confirmed with western blotting six proteins. the altered proteins were analyzed using the software program pathway studio and the biological network can be accessed via (http://life-health.jnu.edu.cn/pathway/pathway.html). further functional studies showed that annexin a1 knock down modestly induces lethality alone and potentiates the effects of dexamethasone on both dexamethasone-sensitive and dexamethasone-resistant mm cells. by correlating the proteomic data with these functional studies, the current results provide not only new insights into the pathogenesis of mm but also direct implications for the development of novel anti-mm therapeutic strategies and could lead to the discovery of potential therapeutic targets. future molecular and functional studies would provide novel insights into the roles of these dysregulated proteins in the molecular etiology of mm. |
| WOS关键词 | HUMAN LEUKEMIC-CELLS ; BREAST-CANCER CELLS ; INDUCED APOPTOSIS ; UP-REGULATION ; BONE-MARROW ; ANNEXIN A1 ; IN-VIVO ; PROTEASOME ; PROTEIN ; EXPRESSION |
| WOS研究方向 | Biochemistry & Molecular Biology |
| WOS类目 | Biochemical Research Methods ; Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000272513500010 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375603 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Ge, Feng |
| 作者单位 | 1.Jinan Univ, Inst Life & Hlth Engn, Guangzhou 510632, Guangdong, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Peoples R China 3.Jinan Univ, Affiliated Hosp 1, Dept Hematol, Guangzhou 510632, Guangdong, Peoples R China 4.So Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, Chuan-Le,Zhang, Zhi-Ping,Xiong, Sheng,et al. Comparative proteomic analysis to discover potential therapeutic targets in human multiple myeloma[J]. Proteomics clinical applications,2009,3(11):1348-1360. |
| APA | Xiao, Chuan-Le.,Zhang, Zhi-Ping.,Xiong, Sheng.,Lu, Chun-Hua.,Wei, Hong-Ping.,...&Ge, Feng.(2009).Comparative proteomic analysis to discover potential therapeutic targets in human multiple myeloma.Proteomics clinical applications,3(11),1348-1360. |
| MLA | Xiao, Chuan-Le,et al."Comparative proteomic analysis to discover potential therapeutic targets in human multiple myeloma".Proteomics clinical applications 3.11(2009):1348-1360. |
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来源：武汉病毒研究所
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