Controlling gel structure to modulate cell adhesion and spreading on the surface of microcapsules
文献类型：期刊论文
| 作者 | Zheng, Huizhen1,2; Gao, Meng1,2; Ren, Ying1,2; Lou, Ruyun1,2; Xie, Hongguo1; Yu, Weiting1; Liu, Xiudong3; Ma, Xiaojun1 |
| 刊名 | Acs applied materials & interfaces
 |
| 出版日期 | 2016-08-03 |
| 卷号 | 8期号:30页码:19333-19342 |
| 关键词 | Alginate-chitosan microcapsule Gel structure Protonated amino Cell adhesion and spreading Surface property |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.6b05778 |
| 通讯作者 | Yu, weiting(yuwt@dicp.ac.cn) ; Liu, xiudong(liuxd@dicp.ac.cn) |
| 英文摘要 | The surface properties of implanted materials or devices play critical roles in modulating cell behavior. however, the surface properties usually affect cell behaviors synergetically so that it is, still difficult to separately investigate the influence of a single property on cell behavior in practical applications. in this study, alginate chitosan (ac) microcapsules with a dense or loose gel structure were fabricated to understand the effect of gel structure on cell behavior. cells preferentially adhered and spread on the loose gel structure microcapsules-rather than on the dense ones. the two types of microcapsules exhibited nearly identical surface positive charges, roughness, stiffness, and hydrophilicity; thus, the result suggested that the gel structure was the principal factor affecting cell behavior. x-ray photoelectron spectroscopy analyses demonstrated that the overall percentage of positively charged amino groups was similar on both microcapsules. the different gel structures led to different states and distributions of the, positively charged amino groups of chitosan, so we conclude that the loose gel structure facilitated greater cell adhesion and spreading mainly because more protonated amino groups remained unbound and exposed on the surface of these microcapsules. |
| WOS关键词 | ALGINATE-BASED MICROCAPSULES ; PANCREATIC-ISLETS ; CHITOSAN ; BIOCOMPATIBILITY ; ENCAPSULATION ; MICROSPHERES ; TISSUE |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000380968300018 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375616 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yu, Weiting; Liu, Xiudong |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, 457 Zhongshan Rd, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Dalian Univ, Coll Environm & Chem Engn, Dalian Econ Technol Dev Zone, Dalian 116622, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Huizhen,Gao, Meng,Ren, Ying,et al. Controlling gel structure to modulate cell adhesion and spreading on the surface of microcapsules[J]. Acs applied materials & interfaces,2016,8(30):19333-19342. |
| APA | Zheng, Huizhen.,Gao, Meng.,Ren, Ying.,Lou, Ruyun.,Xie, Hongguo.,...&Ma, Xiaojun.(2016).Controlling gel structure to modulate cell adhesion and spreading on the surface of microcapsules.Acs applied materials & interfaces,8(30),19333-19342. |
| MLA | Zheng, Huizhen,et al."Controlling gel structure to modulate cell adhesion and spreading on the surface of microcapsules".Acs applied materials & interfaces 8.30(2016):19333-19342. |
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来源：中国科学院大学
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