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Leucine in obesity: therapeutic prospects

文献类型：期刊论文

作者Yao, Kang1,2,3,4; Duan, Yehui1,2,3,6; Li, Fengna1,2,3,7,8; Tan, Bie1,2,3,7,8; Hou, Yongqing9; Wu, Guoyao1,2,3,9,10; Yin, Yulong1,2,3,4,5,11
刊名Trends in pharmacological sciences
出版日期2016-08-01
卷号37期号:8页码:714-727
ISSN号0165-6147
DOI10.1016/j.tips.2016.05.004
通讯作者Li, fengna(lifengna@isa.ac.cn) ; Yin, yulong(yinyulong@isa.ac.cn)
英文摘要Obesity develops from an imbalance of energy homeostasis and is associated with chronic low-grade inflammation in white adipose tissues (wat). inflammation is involved in the pathophysiology of many obesity-induced disorders including insulin resistance and diabetes. increasing evidence has shown that dietary leucine supplementation positively affects the parameters associated with obesity and obesity-related metabolic disorders. the beneficial effects include increased loss of body weight, reduced wat inflammation, improved lipid and glucose metabolism, enhanced mitochondrial function, and preserved lean body mass. although these beneficial effects have not been clearly established, dietary leucine supplementation, either alone or as part of a therapeutic regimen, may be a good nutritional tool in the prevention and management of obesity and obesity-induced metabolic disorders.
WOS关键词CHAIN AMINO-ACIDS ; ACTIVATED PROTEIN-KINASE ; ADIPOSE-TISSUE INFLAMMATION ; SKELETAL-MUSCLE CELLS ; REGULATES FOOD-INTAKE ; NECROSIS-FACTOR-ALPHA ; DIET-INDUCED OBESITY ; HIGH-FAT DIET ; INSULIN-RESISTANCE ; WEIGHT-LOSS
WOS研究方向Pharmacology & Pharmacy
WOS类目Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000381169900010
出版者ELSEVIER SCIENCE LONDON
URI标识http://www.irgrid.ac.cn/handle/1471x/2375631
专题中国科学院大学
通讯作者Li, Fengna; Yin, Yulong
作者单位1.Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Hunan, Peoples R China
2.Hunan Prov Engn Res Ctr Hlth Livestock & Poultry, Changsha 410125, Hunan, Peoples R China
3.Minist Agr, Sci Observing & Expt Stn Anim Nutr & Feed Sci Sou, Changsha 410125, Hunan, Peoples R China
4.Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China
5.Hunan Normal Univ, Coll Life Sci, Changsha 410128, Hunan, Peoples R China
6.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
7.Hunan Collaborat Innovat Ctr Utilizat Bot Funct I, Changsha 410128, Hunan, Peoples R China
8.CICAPS, Hunan Coinnovat Ctr Anim Prod Safety, Changsha 410128, Hunan, Peoples R China
9.Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China
10.Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA
推荐引用方式
GB/T 7714		 Yao, Kang,Duan, Yehui,Li, Fengna,et al. Leucine in obesity: therapeutic prospects[J]. Trends in pharmacological sciences,2016,37(8):714-727.
APA Yao, Kang.,Duan, Yehui.,Li, Fengna.,Tan, Bie.,Hou, Yongqing.,...&Yin, Yulong.(2016).Leucine in obesity: therapeutic prospects.Trends in pharmacological sciences,37(8),714-727.
MLA Yao, Kang,et al."Leucine in obesity: therapeutic prospects".Trends in pharmacological sciences 37.8(2016):714-727.

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