Plasma lipidomics reveals potential lipid markers of major depressive disorder
文献类型：期刊论文
| 作者 | Liu, Xinyu1,2; Li, Jia1,2; Zheng, Peng3,4,5; Zhao, Xinjie1; Zhou, Chanjuan3,4,5; Hu, Chunxiu1; Hou, Xiaoli1; Wang, Haiyang3,4,5; Xie, Peng3,4,5; Xu, Guowang1 |
| 刊名 | Analytical and bioanalytical chemistry
 |
| 出版日期 | 2016-09-01 |
| 卷号 | 408期号:23页码:6497-6507 |
| 关键词 | Major depressive disorder Non-targeted lipidomics Diagnostic biomarker Uplc-ms |
| ISSN号 | 1618-2642 |
| DOI | 10.1007/s00216-016-9768-5 |
| 通讯作者 | Xie, peng(xiepeng@cqmu.edu.cn) ; Xu, guowang(xugw@dicp.ac.cn) |
| 英文摘要 | Major depressive disorder (mdd) is a grave debilitating mental disease with a high incidence and severely impairs quality of life. therefore, its physiopathological basis study and diagnostic biomarker discovery are extremely valuable. in this study, a non-targeted lipidomics strategy using ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (uplc-q-tof/ms) was performed to reveal differential lipids between mdd (n = 60) and healthy controls (hcs, n = 60). validation of changed lipid species was performed in an independent batch including 75 mdd and 52 hc using the same lipidomic method. pronouncedly changed lipid species in mdd were discovered, which mainly were lysophosphatidylcholine (lpc), lysophosphatidylethanolamine (lpe), phosphatidylcholine (pc), phosphatidylethanolamine (pe), phosphatidylinositol (pi), 1-o-alkyl-2-acyl-pe (pe o), 1-o-alkyl-2-acyl-pc (pc o), sphingomyelin (sm), diacylglycerol (dg), and triacylglycerol (tg). among these lipid species, lpc, lpe, pc, pe, pi, tg, etc. remarkably increased in mdd and showed pronounced positive relationships with depression severity, while 1-o-alkyl-2-acyl-pe and sm with odd summed carbon number significantly decreased in mdd and demonstrated negative relationships with depression severity. a combinational lipid panel including lpe 20:4, pc 34:1, pi 40:4, sm 39:1, 2, and tg 44:2 was defined as potential diagnostic biomarker with a good sensitivity and specificity for distinguishing mdd from hcs. our study brings insights into lipid metabolism disorder in mdd and provides a specific potential biomarker for mdd diagnose. |
| WOS关键词 | CARDIOVASCULAR-DISEASE ; MASS-SPECTROMETRY ; HEART-DISEASE ; RAT MODEL ; BRAIN ; BIOMARKERS ; IDENTIFICATION ; TRIGLYCERIDES ; VALIDATION ; METABOLISM |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| WOS类目 | Biochemical Research Methods ; Chemistry, Analytical |
| 语种 | 英语 |
| WOS记录号 | WOS:000382681900026 |
| 出版者 | SPRINGER HEIDELBERG |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375650 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xie, Peng; Xu, Guowang |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Liaoning, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing 400016, Peoples R China 4.Chongqing Med Univ, Inst Neurosci, Chongqing 400016, Peoples R China 5.Chongqing Med Univ, Collaborat Innovat Ctr Brain Sci, Chongqing 400016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xinyu,Li, Jia,Zheng, Peng,et al. Plasma lipidomics reveals potential lipid markers of major depressive disorder[J]. Analytical and bioanalytical chemistry,2016,408(23):6497-6507. |
| APA | Liu, Xinyu.,Li, Jia.,Zheng, Peng.,Zhao, Xinjie.,Zhou, Chanjuan.,...&Xu, Guowang.(2016).Plasma lipidomics reveals potential lipid markers of major depressive disorder.Analytical and bioanalytical chemistry,408(23),6497-6507. |
| MLA | Liu, Xinyu,et al."Plasma lipidomics reveals potential lipid markers of major depressive disorder".Analytical and bioanalytical chemistry 408.23(2016):6497-6507. |
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来源：中国科学院大学
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