Electrical coupling regulates layer 1 interneuron microcircuit formation in the neocortex
文献类型：期刊论文
| 作者 | Yao, Xing-Hua1,2; Wang, Min1,2; He, Xiang-Nan3,4; He, Fei5; Zhang, Shu-Qing1,2; Lu, Wenlian3,4; Qiu, Zi-Long6,7,8; Yu, Yong-Chun1,2 |
| 刊名 | Nature communications
 |
| 出版日期 | 2016-08-01 |
| 卷号 | 7页码:15 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/ncomms12229 |
| 通讯作者 | Yu, yong-chun(ycyu@fudan.edu.cn) |
| 英文摘要 | The coexistence of electrical and chemical synapses among interneurons is essential for interneuron function in the neocortex. however, it remains largely unclear whether electrical coupling between interneurons influences chemical synapse formation and microcircuit assembly during development. here, we show that electrical and gabaergic chemical connections robustly develop between interneurons in neocortical layer 1 over a similar time course. electrical coupling promotes action potential generation and synchronous firing between layer 1 interneurons. furthermore, electrically coupled interneurons exhibit strong gaba-a receptor-mediated synchronous synaptic activity. disruption of electrical coupling leads to a loss of bidirectional, but not unidirectional, gabaergic connections. moreover, a reduction in electrical coupling induces an increase in excitatory synaptic inputs to layer 1 interneurons. together, these findings strongly suggest that electrical coupling between neocortical interneurons plays a critical role in regulating chemical synapse development and precise formation of circuits. |
| WOS关键词 | THALAMIC RETICULAR NUCLEUS ; GAP-JUNCTIONS ; INHIBITORY INTERNEURONS ; CORTICAL INTERNEURONS ; GABAERGIC NEURONS ; SOMATOSENSORY CORTEX ; FIRING SYNCHRONY ; AUDITORY-CORTEX ; CEREBRAL-CORTEX ; RAT NEOCORTEX |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000381524200001 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375654 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yu, Yong-Chun |
| 作者单位 | 1.Fudan Univ, Inst Neurobiol, Inst Brain Sci, State Key Lab Med Neurobiol, Shanghai 200032, Peoples R China 2.Fudan Univ, Collaborat Innovat Ctr Brain Sci, Shanghai 200032, Peoples R China 3.Fudan Univ, Ctr Computat Syst Biol, Shanghai 200433, Peoples R China 4.Fudan Univ, Sch Math Sci, Shanghai 200433, Peoples R China 5.Tongji Univ, Sch Med, Tongji Hosp, Stem Cell Translat Res Ctr, Shanghai 200092, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China 8.Univ Chinese Acad Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yao, Xing-Hua,Wang, Min,He, Xiang-Nan,et al. Electrical coupling regulates layer 1 interneuron microcircuit formation in the neocortex[J]. Nature communications,2016,7:15. |
| APA | Yao, Xing-Hua.,Wang, Min.,He, Xiang-Nan.,He, Fei.,Zhang, Shu-Qing.,...&Yu, Yong-Chun.(2016).Electrical coupling regulates layer 1 interneuron microcircuit formation in the neocortex.Nature communications,7,15. |
| MLA | Yao, Xing-Hua,et al."Electrical coupling regulates layer 1 interneuron microcircuit formation in the neocortex".Nature communications 7(2016):15. |
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来源：中国科学院大学
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