Broader hiv-1 neutralizing antibody responses induced by envelope glycoprotein mutants based on the eiav attenuated vaccine
文献类型：期刊论文
| 作者 | Liu, Lianxing1,2,3; Wan, Yanmin1,4; Wu, Lan1; Sun, Jianping1; Li, Huiguang1; Li, Haishan1; Ma, Liying1; Shao, Yiming1,2 |
| 刊名 | Retrovirology
 |
| 出版日期 | 2010-09-01 |
| 卷号 | 7页码:13 |
| ISSN号 | 1742-4690 |
| DOI | 10.1186/1742-4690-7-71 |
| 通讯作者 | Shao, yiming(yshao@bbn.cn) |
| 英文摘要 | Background: in order to induce a potent and cross-reactive neutralizing antibody (nab), an effective envelope immunogen is crucial for many viral vaccines, including the vaccine for the human immunodeficiency virus (hiv). the chinese equine infectious anemia virus (eiav) attenuated vaccine has controlled the epidemic of this virus after its vaccination in over 70 million equine animals during the last 3 decades in china. data from our past studies demonstrate that the env protein of this vaccine plays a pivotal role in protecting horses from both homologous and heterogeneous eiav challenges. therefore, the amino acid sequence information from the chinese eiav attenuated vaccine, in comparison with the parental wild-type eiav strains, was applied to modify the corresponding region of the envelope glycoprotein of hiv-1 cn54. the direction of the mutations was made towards the amino acids conserved in the two eiav vaccine strains, distinguishing them from the two wild-type strains. the purpose of the modification was to enhance the immunogenicity of the hiv env. results: the induced nab by the modified hiv env neutralized hiv-1 b and b'/c viruses at the highest titer of 1:270. further studies showed that a single amino acid change in the c1 region accounts for the substantial enhancement in induction of anti-hiv-1 neutralizing antibodies. conclusions: this study shows that an hiv envelope modified by the information of another lentivirus vaccine induces effective broadly neutralizing antibodies. a single amino acid mutation was found to increase the immunogenicity of the hiv env. |
| WOS关键词 | INFECTIOUS-ANEMIA VIRUS ; HUMAN-IMMUNODEFICIENCY-VIRUS ; IMMUNE-RESPONSES ; RHESUS MACAQUES ; PROTECTION ; LENTIVIRUS ; CHALLENGE ; REPLICATION ; MATURATION ; GP120 |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000282565200001 |
| 出版者 | BIOMED CENTRAL LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375681 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Shao, Yiming |
| 作者单位 | 1.Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Natl Ctr AIDS STD Control & Prevent, Beijing 102206, Peoples R China 2.Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China 3.Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA 4.Fudan Univ, Sci Res Dept, Shanghai Publ Hlth Clin Ctr, Publ Hlth Clin Ctr, Shanghai 201508, MD, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Lianxing,Wan, Yanmin,Wu, Lan,et al. Broader hiv-1 neutralizing antibody responses induced by envelope glycoprotein mutants based on the eiav attenuated vaccine[J]. Retrovirology,2010,7:13. |
| APA | Liu, Lianxing.,Wan, Yanmin.,Wu, Lan.,Sun, Jianping.,Li, Huiguang.,...&Shao, Yiming.(2010).Broader hiv-1 neutralizing antibody responses induced by envelope glycoprotein mutants based on the eiav attenuated vaccine.Retrovirology,7,13. |
| MLA | Liu, Lianxing,et al."Broader hiv-1 neutralizing antibody responses induced by envelope glycoprotein mutants based on the eiav attenuated vaccine".Retrovirology 7(2010):13. |
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来源：武汉病毒研究所
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