Efficacy of inactivated vaccine against h5n1 influenza virus infection in mice with type 1 diabetes
文献类型：期刊论文
| 作者 | Wu, J.1; Zhang, F.1; Fang, F.1; Chang, H.1; Wang, F.2; Yang, Z.4; Sun, B.5; Chen, Z.1,3,4 |
| 刊名 | Vaccine
 |
| 出版日期 | 2010-03-24 |
| 卷号 | 28期号:15页码:2775-2781 |
| 关键词 | Influenza H5n1 Inactivated vaccine Type 1 diabetes mellitus |
| ISSN号 | 0264-410X |
| DOI | 10.1016/j.vaccine.2010.01.037 |
| 通讯作者 | Chen, z.(chenze2005@hotmail.com) |
| 英文摘要 | We sought to determine susceptibility to highly pathogenic avian influenza (hpai) h5n1 virus and to explore immune protection of inactivated h5n1 vaccine in streptozotocin-induced type 1 diabetic mice. susceptibility of diabetic mice to an h5n1 virus was evaluated by comparing the median lethal dose (ld50) and the lung virus titers with those of the healthy after the viral infection. to evaluate the influence of diabetes on vaccination, diabetic and healthy mice were immunized once with an inactivated h5n1 vaccine and then challenged with a lethal dose of h5n1 virus. the antibody responses, survival rates, lung virus titers and body weight changes were tested. mice with type 1 diabetes had higher lung virus titers and lower survival rates than healthy mice after h5n1 virus infection. inactivated h5n1 vaccine induced protective antibody in diabetic mice, but the antibody responses were postponed and weakened. in spite of this, diabetic mice could be protected against the lethal virus challenge by a single dose of immunization when the amount of the antigen increased. these results indicated that type 1 diabetic mice were more susceptible to h5n1 influenza virus infection than healthy mice, and can be effectively protected by inactivated h5n1 vaccine with increased antigen. (c) 2010 elsevier ltd. all rights reserved. |
| WOS关键词 | HEMAGGLUTININ VACCINE ; IMMUNE-RESPONSE ; MELLITUS ; IMMUNOGENICITY ; PROTECTION ; SAFETY ; RISK ; IMMUNIZATION ; CHALLENGE ; PEOPLE |
| WOS研究方向 | Immunology ; Research & Experimental Medicine |
| WOS类目 | Immunology ; Medicine, Research & Experimental |
| 语种 | 英语 |
| WOS记录号 | WOS:000276174600014 |
| 出版者 | ELSEVIER SCI LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375682 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Chen, Z. |
| 作者单位 | 1.Hunan Normal Univ, Coll Life Sci, Changsha 410081, Hunan, Peoples R China 2.Cent S Univ, Dept Immunol, Xiangya Sch Med, Changsha 410078, Hunan, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 4.Shanghai Inst Biol Prod, Shanghai 200052, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Pasteur Shanghai, Shanghai 200025, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, J.,Zhang, F.,Fang, F.,et al. Efficacy of inactivated vaccine against h5n1 influenza virus infection in mice with type 1 diabetes[J]. Vaccine,2010,28(15):2775-2781. |
| APA | Wu, J..,Zhang, F..,Fang, F..,Chang, H..,Wang, F..,...&Chen, Z..(2010).Efficacy of inactivated vaccine against h5n1 influenza virus infection in mice with type 1 diabetes.Vaccine,28(15),2775-2781. |
| MLA | Wu, J.,et al."Efficacy of inactivated vaccine against h5n1 influenza virus infection in mice with type 1 diabetes".Vaccine 28.15(2010):2775-2781. |
入库方式： iSwitch采集
来源：武汉病毒研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。