Global transcriptome analysis for identification of interactions between coding and noncoding rnas during human erythroid differentiation
文献类型：期刊论文
| 作者 | Ding, Nan1,3; Xi, Jiafei2,4; Li, Yanming1; Xie, Xiaoyan2,4; Shi, Jian1,3; Zhang, Zhaojun1; Li, Yanhua2,4; Fang, Fang2,4; Wang, Sihan2,4; Yue, Wen2,4 |
| 刊名 | Frontiers of medicine
 |
| 出版日期 | 2016-09-01 |
| 卷号 | 10期号:3页码:297-310 |
| 关键词 | Erythroid differentiation Hematopoietic stem cell Rna-seq Mirna Lncrna |
| ISSN号 | 2095-0217 |
| DOI | 10.1007/s11684-016-0452-0 |
| 通讯作者 | Pei, xuetao(peixt@nic.bmi.ac.cn) ; Fang, xiangdong(fangxd@big.ac.cn) |
| 英文摘要 | Studies on coding genes, mirnas, and lncrnas during erythroid development have been performed in recent years. however, analysis focusing on the integration of the three rna types has yet to be done. in the present study, we compared the dynamics of coding genes, mirna, and lncrna expression profiles. to explore dynamic changes in erythropoiesis and potential mechanisms that control these changes in the transcriptome level, we took advantage of high throughput sequencing technologies to obtain transcriptome data from cord blood hematopoietic stem cells and the following four erythroid differentiation stages, as well as from mature red blood cells. results indicated that lncrnas were promising cell marker candidates for erythroid differentiation. clustering analysis classified the differentially expressed genes into four subtypes that corresponded to dynamic changes during stemness maintenance, mid-differentiation, and maturation. integrated analysis revealed that noncoding rnas potentially participated in controlling blood cell maturation, and especially associated with heme metabolism and responses to oxygen species and dna damage. these regulatory interactions were displayed in a comprehensive network, thereby inferring correlations between rnas and their associated functions. these data provided a substantial resource for the study of normal erythropoiesis, which will permit further investigation and understanding of erythroid development and acquired erythroid disorders. |
| WOS关键词 | MALIGNANT HEMATOPOIESIS ; HUMAN ERYTHROPOIESIS ; GENE ; EXPRESSION ; REVEALS ; MICRORNA ; REGULATORS ; NETWORKS ; SEQ ; PROLIFERATION |
| WOS研究方向 | Oncology ; Research & Experimental Medicine |
| WOS类目 | Oncology ; Medicine, Research & Experimental |
| 语种 | 英语 |
| WOS记录号 | WOS:000382863300007 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375685 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Pei, Xuetao; Fang, Xiangdong |
| 作者单位 | 1.Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genome Sci & Informat, Beijing 100101, Peoples R China 2.Acad Mil Med Sci, Beijing Inst Transfus Med, Lab Stem Cell & Regenerat Med, Beijing 100850, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Acad Mil Med Sci, South China Res Ctr Stem Cell & Regenerat Med, Guangzhou 510300, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, Nan,Xi, Jiafei,Li, Yanming,et al. Global transcriptome analysis for identification of interactions between coding and noncoding rnas during human erythroid differentiation[J]. Frontiers of medicine,2016,10(3):297-310. |
| APA | Ding, Nan.,Xi, Jiafei.,Li, Yanming.,Xie, Xiaoyan.,Shi, Jian.,...&Fang, Xiangdong.(2016).Global transcriptome analysis for identification of interactions between coding and noncoding rnas during human erythroid differentiation.Frontiers of medicine,10(3),297-310. |
| MLA | Ding, Nan,et al."Global transcriptome analysis for identification of interactions between coding and noncoding rnas during human erythroid differentiation".Frontiers of medicine 10.3(2016):297-310. |
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来源：中国科学院大学
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