Hiv-specific il-2(+) and/or ifn-gamma(+) cd8(+)t cell reponses during chronic hiv-1 infection in former blood donors
文献类型：期刊论文
| 作者 | Feng, Yan-Meng1,2,3,4; Wan, Yan-Min3; Liu, Lian-Xin1,3,4; Qiu, Chao1,3,4; Ma, Peng-Fei3; Peng, Hong3; Ruan, Yu-Hua3; Han, Li-Feng3; Hong, Kun-Xue3; Xing, Hui3 |
| 刊名 | Biomedical and environmental sciences
 |
| 出版日期 | 2010-10-01 |
| 卷号 | 23期号:5页码:391-401 |
| 关键词 | Hiv-1 Subtype b' Cd8 t cell response Ifn-gamma Il-2 Ics |
| ISSN号 | 0895-3988 |
| 通讯作者 | Shao, yi-ming(yshao@bbn.cn) |
| 英文摘要 | Objective conflicting data have been generated from previous studies to determine which kind of relationship exists between hiv-1 specific cd8 tcell responses and hiv-1 viral load or cd4 count over the course of infection. in this study, 153 hiv-1 infected ltnps were enrolled to investigate the role of hiv-1 specific cd8 t-cell responses in chronic hiv-1 infection among hiv-1 infected former blood donors. methods the patients were stratified into three groups according to cd4 count: cd4 >= 500 cells/mu l; 350 cells/mu l <= cd4<500 cells/mu l; cd4<350 cells/mu l. pbmcs were isolated from the patients' anticoagulated blood samples. il-2 and ifn-gamma secretions of cd 8 t cells against 17 hiv-1 consensus b full peptide pools were analyzed by using ics assay. results an overall inverse correlation were observed between cd4 count and plasma viral load. although no significant difference was observed during the comparisons of frequency/breadth of hiv-1 specific cd8 t cell responses, cd4 count stratification analysis showed that different correlation pattern existed in three strata: as for patients whose cd4 counts were less than 350 cells/mu l, no significant correlations were identified between frequency/breadth of hiv-1 specific cd8 t cell responses and cd4 count/viral load; as for patients whose cd4 counts ranged from 350 cells/mu l to 500 cells/mu l, significant correlation was only observed between the response breadth of il-2+ifn-gamma+ cd8 t cells and cd4 count; however, as for patients whose cd4 counts were more than 500 cells/mu l, direct correlations were identified between il-2+ifn-gamma+/il-2+/ifn-gamma+ cd8 t cells and viral load or cd4 count. conclusions universal consistent inverse correlation was only indentified between cd4 count and viral load. the relationship between hiv-1 specific cd8 t cell responses and cd4 count/viral load varied in different cd4 strata, which showed that better preserved cd4 t cells were correlated with better cd8 t cell functions. |
| WOS关键词 | SIMIAN-IMMUNODEFICIENCY-VIRUS ; CYTOTOXIC T-LYMPHOCYTES ; VIRAL LOAD ; ANTIRETROVIRAL THERAPY ; TYPE-1 INFECTION ; RHESUS-MONKEYS ; RESPONSES ; VIREMIA ; PLASMA ; MACAQUES |
| WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health |
| WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health |
| 语种 | 英语 |
| WOS记录号 | WOS:000284393500009 |
| 出版者 | CHINESE CENTER DISEASE CONTROL & PREVENTION |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375690 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Shao, Yi-Ming |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 2.Chinese Ctr Dis Control & Prevent, Inst Communicable Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China 3.Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 100050, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Yan-Meng,Wan, Yan-Min,Liu, Lian-Xin,et al. Hiv-specific il-2(+) and/or ifn-gamma(+) cd8(+)t cell reponses during chronic hiv-1 infection in former blood donors[J]. Biomedical and environmental sciences,2010,23(5):391-401. |
| APA | Feng, Yan-Meng.,Wan, Yan-Min.,Liu, Lian-Xin.,Qiu, Chao.,Ma, Peng-Fei.,...&Shao, Yi-Ming.(2010).Hiv-specific il-2(+) and/or ifn-gamma(+) cd8(+)t cell reponses during chronic hiv-1 infection in former blood donors.Biomedical and environmental sciences,23(5),391-401. |
| MLA | Feng, Yan-Meng,et al."Hiv-specific il-2(+) and/or ifn-gamma(+) cd8(+)t cell reponses during chronic hiv-1 infection in former blood donors".Biomedical and environmental sciences 23.5(2010):391-401. |
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来源：武汉病毒研究所
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