Dual-sensitive charge-conversional polymeric prodrug for efficient codelivery of demethylcantharidin and doxorubicin
文献类型：期刊论文
| 作者 | Wu, Yanjuan1,2; Zhou, Dongfang1; Zhang, Qingfei1,2; Xie, Zhigang1; Chen, Xuesi3; Jing, Xiabin1; Huang, Yubin1 |
| 刊名 | Biomacromolecules
 |
| 出版日期 | 2016-08-01 |
| 卷号 | 17期号:8页码:2650-2661 |
| ISSN号 | 1525-7797 |
| DOI | 10.1021/acs.biomac.6b00705 |
| 通讯作者 | Zhou, dongfang(east@ciac.ac.cn) ; Huang, yubin(ybhuang@ciac.ac.cn) |
| 英文摘要 | A tumor is a complicated system, and tumor cells are typically heterogeneous in many aspects. polymeric drug delivery nanocarriers sensitive to a single type of biosignals may not release cargos effectively in all tumor cells, leading to low therapeutic efficacy. to address the challenges, here, we demonstrated a ph/ reduction dual-sensitive charge-conversional polymeric prodrug strategy for efficient codelivery. reduction-sensitive disulfide group and acid-labile anticancer drug (demethylcantharidin, dmc)-conjugated beta-carboxylic amide group were repeatedly and regularly introduced into copolymer chain simultaneously via facile cuaac click polymerization. the obtained multifunctional polymeric prodrug p(dmc), mpeg-b-poly(disulfide-alt-demethylcantharidin)-b-mpeg was further utilized for dox encapsulation. under tumor tissue/cell microenvironments (ph 6.5 and 10 mm gsh), the dox-loaded polymeric prodrug nanoparticles (p(dmc)@dox nps) performed surface negative-to-positive charge conversion and accelerated/sufficient release of dmc and dox. the remarkably enhanced cellular internalization and cytotoxicity in vitro, especially against dox-resistant smmc7721 cells, were demonstrated. p(dmc)@dox nps in vivo also exhibited higher tumor accumulation and improved antitumor efficiency compared to p(sa)@dox nps with one drug and without charge-conversion ability. the desired multifunctional polymeric prodrug strategy brings a new opportunity for cancer chemotherapy. |
| WOS关键词 | INTRACELLULAR DRUG-DELIVERY ; CANCER-CHEMOTHERAPY ; CLICK POLYMERIZATION ; TRIBLOCK COPOLYMER ; CO-DELIVERY ; PH ; NANOPARTICLES ; MICELLES ; REDUCTION ; CONJUGATE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000381231600016 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375695 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhou, Dongfang; Huang, Yubin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Ecomat, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Yanjuan,Zhou, Dongfang,Zhang, Qingfei,et al. Dual-sensitive charge-conversional polymeric prodrug for efficient codelivery of demethylcantharidin and doxorubicin[J]. Biomacromolecules,2016,17(8):2650-2661. |
| APA | Wu, Yanjuan.,Zhou, Dongfang.,Zhang, Qingfei.,Xie, Zhigang.,Chen, Xuesi.,...&Huang, Yubin.(2016).Dual-sensitive charge-conversional polymeric prodrug for efficient codelivery of demethylcantharidin and doxorubicin.Biomacromolecules,17(8),2650-2661. |
| MLA | Wu, Yanjuan,et al."Dual-sensitive charge-conversional polymeric prodrug for efficient codelivery of demethylcantharidin and doxorubicin".Biomacromolecules 17.8(2016):2650-2661. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。