Ns-based live attenuated h1n1 pandemic vaccines protect mice and ferrets
文献类型：期刊论文
| 作者 | Zhou, Bin1,2; Li, Yan1,3; Belser, Jessica A.4; Pearce, Melissa B.4; Schmolke, Mirco5; Subba, Anju X.1; Shi, Zhengli3; Zaki, Sherif R.6; Blau, Dianna M.6; Garcia-Sastre, Adolfo5,7,8 |
| 刊名 | Vaccine
 |
| 出版日期 | 2010-11-23 |
| 卷号 | 28期号:50页码:8015-8025 |
| 关键词 | Influenza a virus Live atter uated vaccine Nonstrucural protein |
| ISSN号 | 0264-410X |
| DOI | 10.1016/j.vaccine.2010.08.106 |
| 通讯作者 | Wentworth, david e.(dew05@health.state.ny.us) |
| 英文摘要 | Although vaccines against influenza a virus are the most effective method to combat infection, it is clear that their production needs to be accelerated and their efficacy improved. we generated live attenuated human influenza a vaccines (laivs) by rationally engineering mutations directly into the genome of a pandemic-hi ni virus. two laivs (ns1-73 and ns1-126) were based on the success of laivs for animal influenza a viruses. a third candidate (ns delta 5) is a unique ns-mutant that has never been used as a laiv. the vaccine potential of each laiv was determined through analysis of attenuation, interferon production, immunogenicity, and their ability to protect mice and ferrets. this study demonstrates that nsa5 is an ideal laiv candidate, provides important information on the effects that different ns mutations have on the pandemic-hi ni virus and shows that laivs can be engineered directly from the genomes of emerging/circulating influenza a viruses. (c) 2010 elsevier ltd. all rights reserved. |
| WOS关键词 | INFLUENZA-A VIRUS ; CYTOTOXIC T-LYMPHOCYTES ; ADAPTIVE IMMUNITY ; TEMPERATURE SENSITIVITY ; SEQUENCE VARIATION ; A/ANN ARBOR/6/60 ; GENE-EXPRESSION ; TRUNCATED NS1 ; INTERFERON ; SWINE |
| WOS研究方向 | Immunology ; Research & Experimental Medicine |
| WOS类目 | Immunology ; Medicine, Research & Experimental |
| 语种 | 英语 |
| WOS记录号 | WOS:000285667400025 |
| 出版者 | ELSEVIER SCI LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375709 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Wentworth, David E. |
| 作者单位 | 1.SUNY Albany, New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA 2.SUNY Albany, Sch Publ Hlth, Dept Biomed Sci, Albany, NY 12201 USA 3.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Peoples R China 4.NCIRD, Immunol & Pathogenesis Branch, Influenza Div, Atlanta, GA USA 5.Mt Sinai Sch Med, Dept Microbiol, New York, NY USA 6.Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Atlanta, GA USA 7.Mt Sinai Sch Med, Inst Global Hlth & Emerging Pathogens, New York, NY USA 8.Mt Sinai Sch Med, Dept Med, Div Infect Dis, New York, NY USA |
| 推荐引用方式 GB/T 7714 | Zhou, Bin,Li, Yan,Belser, Jessica A.,et al. Ns-based live attenuated h1n1 pandemic vaccines protect mice and ferrets[J]. Vaccine,2010,28(50):8015-8025. |
| APA | Zhou, Bin.,Li, Yan.,Belser, Jessica A..,Pearce, Melissa B..,Schmolke, Mirco.,...&Wentworth, David E..(2010).Ns-based live attenuated h1n1 pandemic vaccines protect mice and ferrets.Vaccine,28(50),8015-8025. |
| MLA | Zhou, Bin,et al."Ns-based live attenuated h1n1 pandemic vaccines protect mice and ferrets".Vaccine 28.50(2010):8015-8025. |
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来源：武汉病毒研究所
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