Identification of a novel second-generation circulating recombinant form (crf48_01b) in malaysia: a descendant of the previously identified crf33_01b
文献类型：期刊论文
| 作者 | Li, Yue1,2; Tee, Kok Keng1,3,6; Liao, Huanan1; Hase, Saiki1; Uenishi, Rie1; Li, Xiao-Jie1,4; Tsuchiura, Takayo1; Yang, Rongge2; Govindasamy, Sumathi3; Yong, Yean Kong3 |
| 刊名 | Jaids-journal of acquired immune deficiency syndromes
 |
| 出版日期 | 2010-06-01 |
| 卷号 | 54期号:2页码:129-136 |
| 关键词 | Asia Bayesian coalescent analysis Circulating recombinant form Crf33_01b Crf48_01b Injection drug user Malaysia Phylogeny Time of the most recent common ancestor |
| ISSN号 | 1525-4135 |
| DOI | 10.1097/qai.0b013e3181d82ce5 |
| 通讯作者 | Takebe, yutaka(takebe@nih.go.jp) |
| 英文摘要 | A molecular epidemiological investigation conducted among injecting drug users in eastern peninsular malaysia in 2007 identified a cluster of sequences (n = 3) located outside any known hiv-1 genotype. analyses of near full-length nucleotide sequences of these strains from individuals with no recognizable linkage revealed that they have an identical subtype structure comprised of crf01_ae and subtype b', distinct from any known circulating recombinant forms (crfs). this novel crf, designated crf48_01b, is closely related to crf33_01b, previously identified in kuala lumpur. phylogenetic analysis of multiple crf48_01b genome regions showed that crf48_01b forms a monophyletic cluster within crf33_01b, suggesting that this new recombinant is very likely a descendant of crf33_01b. crf48_01b thus represents one of the first examples of a "second-generation'' crf, generated by additional crossover with pre-existing crfs. corroborating these results, bayesian molecular clock analyses indicated that crf48_01b emerged in similar to 2001, approximately similar to 8 years after the emergence of crf33_01b. |
| WOS关键词 | IMMUNODEFICIENCY-VIRUS TYPE-1 ; INJECTING DRUG-USERS ; FULL-LENGTH SEQUENCE ; KUALA-LUMPUR ; CRF01-AE/B RECOMBINANT ; RISK POPULATIONS ; HIV-1 ; THAILAND ; DYNAMICS ; COMPLEX |
| WOS研究方向 | Immunology ; Infectious Diseases |
| WOS类目 | Immunology ; Infectious Diseases |
| 语种 | 英语 |
| WOS记录号 | WOS:000278100600004 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375718 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Takebe, Yutaka |
| 作者单位 | 1.Natl Inst Infect Dis, AIDS Res Ctr, Lab Mol Virol & Epidemiol, Shinjuku Ku, Tokyo 1628640, Japan 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Peoples R China 3.Univ Malaya, Ctr Excellence Res AIDS, Kuala Lumpur, Malaysia 4.Shanghai Jiao Tong Univ, Peoples Hosp 1, Dept Dermatol, Shanghai 200030, Peoples R China 5.Univ Oxford, Dept Zool, Oxford OX1 3PS, England 6.Columbia Univ, Mailman Sch Publ Hlth, Ctr Infect & Immun, New York, NY USA |
| 推荐引用方式 GB/T 7714 | Li, Yue,Tee, Kok Keng,Liao, Huanan,et al. Identification of a novel second-generation circulating recombinant form (crf48_01b) in malaysia: a descendant of the previously identified crf33_01b[J]. Jaids-journal of acquired immune deficiency syndromes,2010,54(2):129-136. |
| APA | Li, Yue.,Tee, Kok Keng.,Liao, Huanan.,Hase, Saiki.,Uenishi, Rie.,...&Takebe, Yutaka.(2010).Identification of a novel second-generation circulating recombinant form (crf48_01b) in malaysia: a descendant of the previously identified crf33_01b.Jaids-journal of acquired immune deficiency syndromes,54(2),129-136. |
| MLA | Li, Yue,et al."Identification of a novel second-generation circulating recombinant form (crf48_01b) in malaysia: a descendant of the previously identified crf33_01b".Jaids-journal of acquired immune deficiency syndromes 54.2(2010):129-136. |
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来源：武汉病毒研究所
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