Intraspecies diversity of sars-like coronaviruses in rhinolophus sinicus and its implications for the origin of sars coronaviruses in humans
文献类型：期刊论文
| 作者 | Yuan, Junfa1; Hon, Chung-Chau2; Li, Yan1; Wang, Dingming3; Xu, Gelin4; Zhang, Huajun1; Zhou, Peng1; Poon, Leo L. M.5; Lam, Tommy Tsan-Yuk2; Leung, Frederick Chi-Ching2 |
| 刊名 | Journal of general virology
 |
| 出版日期 | 2010-04-01 |
| 卷号 | 91页码:1058-1062 |
| ISSN号 | 0022-1317 |
| DOI | 10.1099/vir.0.016378-0 |
| 通讯作者 | Shi, zhengli(zlshi@wh.iov.cn) |
| 英文摘要 | The chinese rufous horseshoe bat (rhinolophus sinicus) has been suggested to carry the direct ancestor of severe acute respiratory syndrome (sars) coronavirus (scov), and the diversity of sars-like covs (slcov) within this rhinolophus species is therefore worth investigating. here, we demonstrate the remarkable diversity of slcovs in r. sinicus and identify a strain with the same pattern of phylogenetic incongruence (i.e. an indication of recombination) as reported previously in another slcov strain. moreover, this strain possesses a distinctive 579 nt deletion in the nsp3 region that was also found in a human scov from the late-phase epidemic. phylogenetic analysis of the orf1 region suggested that the human scovs are phylogenetically closer to slcovs in r. sinicus than to slcovs in other rhinolophus species. these findings reveal a closer evolutionary linkage between scov in humans and slcovs in r. sinicus, defining the scope of surveillance to search for the direct ancestor of human scovs. |
| WOS关键词 | ACUTE RESPIRATORY SYNDROME ; HORSESHOE BATS ; VIRUS ; RECOMBINATION |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Virology |
| WOS类目 | Biotechnology & Applied Microbiology ; Virology |
| 语种 | 英语 |
| 出版者 | SOC GENERAL MICROBIOLOGY |
| WOS记录号 | WOS:000276714300026 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375723 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Shi, Zhengli |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Peoples R China 2.Univ Hong Kong, Sch Biol Sci, Hong Kong, Hong Kong, Peoples R China 3.Dis Control & Prevent Guizhou Prov, Guiyang, Peoples R China 4.Minist Hlth, Wuhan Inst Biol Prod, Wuhan, Peoples R China 5.Univ Hong Kong, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Junfa,Hon, Chung-Chau,Li, Yan,et al. Intraspecies diversity of sars-like coronaviruses in rhinolophus sinicus and its implications for the origin of sars coronaviruses in humans[J]. Journal of general virology,2010,91:1058-1062. |
| APA | Yuan, Junfa.,Hon, Chung-Chau.,Li, Yan.,Wang, Dingming.,Xu, Gelin.,...&Shi, Zhengli.(2010).Intraspecies diversity of sars-like coronaviruses in rhinolophus sinicus and its implications for the origin of sars coronaviruses in humans.Journal of general virology,91,1058-1062. |
| MLA | Yuan, Junfa,et al."Intraspecies diversity of sars-like coronaviruses in rhinolophus sinicus and its implications for the origin of sars coronaviruses in humans".Journal of general virology 91(2010):1058-1062. |
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来源：武汉病毒研究所
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