Cellular model of neuronal atrophy induced by dync1i1 deficiency reveals protective roles of ras-raf-mek signaling
文献类型：期刊论文
| 作者 | Liu, Zhi-Dong1; Zhang, Su1,2; Hao, Jian-Jin1; Xie, Tao-Rong1; Kang, Jian-Sheng1,2 |
| 刊名 | Protein & cell
 |
| 出版日期 | 2016-09-01 |
| 卷号 | 7期号:9页码:638-650 |
| 关键词 | Ras-raf-mek pathway Atrophy Dynein intermediate chain Mitochondria Hippocampal neuron Autophagy |
| ISSN号 | 1674-800X |
| DOI | 10.1007/s13238-016-0301-6 |
| 通讯作者 | Kang, jian-sheng(jskang@sibs.ac.cn) |
| 英文摘要 | Neuronal atrophy is a common pathological feature occurred in aging and neurodegenerative diseases. a variety of abnormalities including motor protein malfunction and mitochondrial dysfunction contribute to the loss of neuronal architecture; however, less is known about the intracellular signaling pathways that can protect against or delay this pathogenic process. here, we show that the dync1i1 deficiency, a neuron-specific dynein intermediate chain, causes neuronal atrophy in primary hippocampal neurons. with this cellular model, we are able to find that activation of ras-raf-mek signaling protects against neuronal atrophy induced by dync1i1 deficiency, which relies on mek-dependent autophagy in neuron. moreover, we further reveal that braf also protects against neuronal atrophy induced by mitochondrial impairment. these findings demonstrate protective roles of the ras-raf-mek axis against neuronal atrophy, and imply a new therapeutic target for clinical intervention. |
| WOS关键词 | INTERMEDIATE CHAIN PHOSPHORYLATION ; CYTOPLASMIC DYNEIN ; ALZHEIMERS-DISEASE ; IN-VITRO ; TRANSPORT ; PATHWAY ; NEURODEGENERATION ; MUTATIONS ; ERK ; DEGENERATION |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000382669000003 |
| 出版者 | HIGHER EDUCATION PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375726 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Kang, Jian-Sheng |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200231, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zhi-Dong,Zhang, Su,Hao, Jian-Jin,et al. Cellular model of neuronal atrophy induced by dync1i1 deficiency reveals protective roles of ras-raf-mek signaling[J]. Protein & cell,2016,7(9):638-650. |
| APA | Liu, Zhi-Dong,Zhang, Su,Hao, Jian-Jin,Xie, Tao-Rong,&Kang, Jian-Sheng.(2016).Cellular model of neuronal atrophy induced by dync1i1 deficiency reveals protective roles of ras-raf-mek signaling.Protein & cell,7(9),638-650. |
| MLA | Liu, Zhi-Dong,et al."Cellular model of neuronal atrophy induced by dync1i1 deficiency reveals protective roles of ras-raf-mek signaling".Protein & cell 7.9(2016):638-650. |
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来源：中国科学院大学
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