Population variation of west nile virus confers a host-specific fitness benefit in mosquitoes
文献类型：期刊论文
| 作者 | Fitzpatrick, Kelly A.1; Deardorff, Eleanor R.1; Pesko, Kendra1; Brackney, Doug E.1; Zhang, Bo2; Bedrick, Edward3; Shi, Pei-Yong4; Ebel, Gregory D.1 |
| 刊名 | Virology
 |
| 出版日期 | 2010-08-15 |
| 卷号 | 404期号:1页码:89-95 |
| 关键词 | West nile virus Flavivirus Arbovirus Fitness Quasispecies Mosquitoes |
| ISSN号 | 0042-6822 |
| DOI | 10.1016/j.virol.2010.04.029 |
| 通讯作者 | Ebel, gregory d.(gebel@salud.unm.edu) |
| 英文摘要 | West nile virus is similar to most other rna viruses in that it exists in nature as a genetically diverse population. however, the role of this genetic diversity within natural transmission cycles and its importance to virus perpetuation remain poorly understood. therefore, we determined whether highly genetically diverse populations are more fit compared to less genetically diverse wnv populations. specifically, we generated three wnv populations that varied in their genetic diversity and evaluated their fitness relative to genetically marked control wnv in vivo in culex quinquefasciatus mosquitoes and chickens. our results demonstrate that high genetic diversity leads to fitness gains in vector mosquitoes, but not chickens. (c) 2010 elsevier inc. all rights reserved. |
| WOS关键词 | NEW-YORK ; ENCEPHALITIS ; ADAPTATION ; RNA ; ARBOVIRUS ; GENOTYPE |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000278958000010 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375740 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Ebel, Gregory D. |
| 作者单位 | 1.Univ New Mexico, Sch Med, Dept Pathol, Albuquerque, NM 87131 USA 2.Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Hubei, Peoples R China 3.Univ New Mexico, Sch Med, Dept Internal Med, Div Epidemiol & Biostat, Albuquerque, NM 87131 USA 4.Novartis Inst Trop Dis, Singapore 138670, Singapore |
| 推荐引用方式 GB/T 7714 | Fitzpatrick, Kelly A.,Deardorff, Eleanor R.,Pesko, Kendra,et al. Population variation of west nile virus confers a host-specific fitness benefit in mosquitoes[J]. Virology,2010,404(1):89-95. |
| APA | Fitzpatrick, Kelly A..,Deardorff, Eleanor R..,Pesko, Kendra.,Brackney, Doug E..,Zhang, Bo.,...&Ebel, Gregory D..(2010).Population variation of west nile virus confers a host-specific fitness benefit in mosquitoes.Virology,404(1),89-95. |
| MLA | Fitzpatrick, Kelly A.,et al."Population variation of west nile virus confers a host-specific fitness benefit in mosquitoes".Virology 404.1(2010):89-95. |
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来源：武汉病毒研究所
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