Near-infrared polymeric nanoparticles with high content of cyanine for bimodal imaging and photothermal therapy
文献类型：期刊论文
| 作者 | Lin, Wenhai1,2; Li, Yang3; Zhang, Wei1,2; Liu, Shi1; Xie, Zhigang1; Jing, Xiabin1 |
| 刊名 | Acs applied materials & interfaces
 |
| 出版日期 | 2016-09-21 |
| 卷号 | 8期号:37页码:24426-24432 |
| 关键词 | Near-infrared Fluorescence imaging Photoacoustic imaging Photothermal therapy |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.6b07103 |
| 通讯作者 | Xie, zhigang(xiez@ciac.ac.cn) |
| 英文摘要 | The discovery and synthesis of theranostic nanomedicines with high loading of imaging and therapeutic agents is challenging. in this work, a polymer assembling strategy was used to make nanoparticles with exceptionally high loading of theranostic agent. as an example, poly(heptamethine) was synthesized via multicomponent passerini reaction, and then assembled into nanoparticles in the presence of poly(ethylene glycol)(2k)-block-poly(nplactide)(2k) (peg-pla) with high heptamethine loading (>50%). the formed nanoparticles could be used for bimodal bioimaging and photothermal therapy. the bimodal bioimaging provided complementary message about biodistribution, and photothermal treatment inhibited the growth of cervical carcinoma upon laser irradiation. this assembly of polymers formed by imaging and therapeutic agents opens new possibilities for the construction of multifunctional nanomedicines. |
| WOS关键词 | VIVO CANCER-THERAPY ; INDOCYANINE GREEN ; PASSERINI REACTION ; DRUG-DELIVERY ; SURGERY ; AGENT ; DYE ; FLUORESCENCE ; MICELLES ; ALBUMIN |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000384033600019 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375741 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xie, Zhigang |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, 5625 Renmin St, Changchun 130022, Jilin, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Yanshan Univ, Coll Environm & Chem Engn, Qinhuangdao 060004, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Wenhai,Li, Yang,Zhang, Wei,et al. Near-infrared polymeric nanoparticles with high content of cyanine for bimodal imaging and photothermal therapy[J]. Acs applied materials & interfaces,2016,8(37):24426-24432. |
| APA | Lin, Wenhai,Li, Yang,Zhang, Wei,Liu, Shi,Xie, Zhigang,&Jing, Xiabin.(2016).Near-infrared polymeric nanoparticles with high content of cyanine for bimodal imaging and photothermal therapy.Acs applied materials & interfaces,8(37),24426-24432. |
| MLA | Lin, Wenhai,et al."Near-infrared polymeric nanoparticles with high content of cyanine for bimodal imaging and photothermal therapy".Acs applied materials & interfaces 8.37(2016):24426-24432. |
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来源：中国科学院大学
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