The ubiquitin ligase trim27 functions as a host restriction factor antagonized by mycobacterium tuberculosis ptpa during mycobacterial infection
文献类型：期刊论文
| 作者 | Wang, Jing1; Teng, Jade L. L.2; Zhao, Dongdong1,3; Ge, Pupu1; Li, Bingxi1; Woo, Patrick C. Y.2; Liu, Cui Hua1,3 |
| 刊名 | Scientific reports
 |
| 出版日期 | 2016-10-04 |
| 卷号 | 6页码:13 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep34827 |
| 通讯作者 | Liu, cui hua(liucuihua@im.ac.cn) |
| 英文摘要 | Macrophage-mediated innate immune responses play crucial roles in host defense against pathogens. recent years have seen an explosion of host proteins that act as restriction factors blocking viral replication in infected cells. however, the essential factors restricting mycobacterium tuberculosis (mtb) and their regulatory roles during mycobacterial infection remain largely unknown. we previously reported that mtb tyrosine phosphatase ptpa, a secreted effector protein required for intracellular survival of mtb, inhibits innate immunity by co-opting the host ubiquitin system. here, we identified a new ptpa-interacting host protein trim27, which is reported to possess a conserved ring domain and usually acts as an e3 ubiquitin ligase that interferes with various cellular processes. we further demonstrated that trim27 restricts survival of mycobacteria in macrophages by promoting innate immune responses and cell apoptosis. interestingly, mtb ptpa could antagonize trim27-promoted jnk/p38 mapk pathway activation and cell apoptosis through competitively binding to the ring domain of trim27. trim27 probably works as a potential restriction factor for mtb and its function is counteracted by mtb effector proteins such as ptpa. our study suggests a potential tuberculosis treatment via targeting of the trim27-ptpa interfaces. |
| WOS关键词 | RET FINGER PROTEIN ; DEPHOSPHORYLATION ; REPLICATION ; ACTIVATION ; MACROPHAGE ; INHIBITION ; VIRULENCE ; PATHWAY ; COMPLEX ; FAMILY |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000384543400001 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375771 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu, Cui Hua |
| 作者单位 | 1.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China 2.Univ Hong Kong, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China 3.Univ Chinese Acad Sci, Savaid Med Sch, Beijing 101408, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jing,Teng, Jade L. L.,Zhao, Dongdong,et al. The ubiquitin ligase trim27 functions as a host restriction factor antagonized by mycobacterium tuberculosis ptpa during mycobacterial infection[J]. Scientific reports,2016,6:13. |
| APA | Wang, Jing.,Teng, Jade L. L..,Zhao, Dongdong.,Ge, Pupu.,Li, Bingxi.,...&Liu, Cui Hua.(2016).The ubiquitin ligase trim27 functions as a host restriction factor antagonized by mycobacterium tuberculosis ptpa during mycobacterial infection.Scientific reports,6,13. |
| MLA | Wang, Jing,et al."The ubiquitin ligase trim27 functions as a host restriction factor antagonized by mycobacterium tuberculosis ptpa during mycobacterial infection".Scientific reports 6(2016):13. |
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来源：中国科学院大学
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