A live bivalent influenza vaccine based on a h9n2 virus strain
文献类型：期刊论文
| 作者 | Wu, Rui1,5; Guan, Yi2; Yang, Zhongdong4; Chen, Jianjun1; Wang, Hanzhong1; Chen, Quanjiao1; Sui, Zhiwei1; Fang, Fang3; Chen, Ze1,3,4 |
| 刊名 | Vaccine
 |
| 出版日期 | 2010-01-08 |
| 卷号 | 28期号:3页码:673-680 |
| 关键词 | Bivalent vaccine Influenza H9n2 Hemagglutinin |
| ISSN号 | 0264-410X |
| DOI | 10.1016/j.vaccine.2009.10.102 |
| 通讯作者 | Chen, ze() |
| 英文摘要 | The purpose of this study was to construct an h9n2 virus-based bivalent live vaccine expressing the protective antigen of a different subtype of influenza virus. reverse genetics was used to generate an influenza virus containing nine gene segments derived from the a/chicken/jiangsu/11/2002 (h9n2) strain, including independent m1 and m2 matrix gene segments a recombinant virus expressing the h1n1 ha1 hemagglutinin protein was produced on this framework by substituting the extracellular domain of the h9n2 m2 gene with the h1n1 ha1 fragment from a/pr/8/34 (pr8. h1n1). the resulting hybrid virus h9n2-pr8/ha1 was genetically stable and of low pathogenicity. intra-nasal immunization of balb/c mice with h9n2-pr8/ha1 virus induced both anti-h9n2 virus and anti-pr8 ha antibodies and conferred protection to mice against lethal challenge (40x ld(50)) with either h1n1 or h9n2 viruses this study provides a new influenza h9n2 virus model for the expression and/or delivery of foreign antigens. (c) 2009 elsevier ltd all rights reserved. |
| WOS关键词 | ION-CHANNEL ACTIVITY ; A-VIRUS ; IMMUNE-RESPONSES ; FOREIGN PROTEIN ; M2 PROTEINS ; BALB/C MICE ; GENERATION ; EXPRESSION ; PROTECTION ; INFECTION |
| WOS研究方向 | Immunology ; Research & Experimental Medicine |
| WOS类目 | Immunology ; Medicine, Research & Experimental |
| 语种 | 英语 |
| WOS记录号 | WOS:000275015200011 |
| 出版者 | ELSEVIER SCI LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375778 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Chen, Ze |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 2.Univ Hong Kong, Queen Mary Hosp, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China 3.Hunan Normal Univ, Coll Life Sci, Changsha 410081, Hunan, Peoples R China 4.Shanghai Inst Biol Prod, Shanghai 200052, Peoples R China 5.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Rui,Guan, Yi,Yang, Zhongdong,et al. A live bivalent influenza vaccine based on a h9n2 virus strain[J]. Vaccine,2010,28(3):673-680. |
| APA | Wu, Rui.,Guan, Yi.,Yang, Zhongdong.,Chen, Jianjun.,Wang, Hanzhong.,...&Chen, Ze.(2010).A live bivalent influenza vaccine based on a h9n2 virus strain.Vaccine,28(3),673-680. |
| MLA | Wu, Rui,et al."A live bivalent influenza vaccine based on a h9n2 virus strain".Vaccine 28.3(2010):673-680. |
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来源：武汉病毒研究所
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