Characterization of an aspartate-dependent acid survival system in yersinia pseudotuberculosis
文献类型：期刊论文
| 作者 | Hu, Yangbo1,2; Lu, Pei1,2; Zhang, Yong1; Li, Lamei1,2; Chen, Shiyun1 |
| 刊名 | Febs letters
 |
| 出版日期 | 2010-06-03 |
| 卷号 | 584期号:11页码:2311-2314 |
| 关键词 | Acid survival Proteomic analysis Aspartate Aspartase Yersinia pseudotuberculosis |
| ISSN号 | 0014-5793 |
| DOI | 10.1016/j.febslet.2010.03.045 |
| 通讯作者 | Chen, shiyun(sychen@wh.iov.cn) |
| 英文摘要 | Enteric bacteria have developed various survival systems that protect against acid stress. in this study, an aspartate-dependent acid survival system is characterized in yersinia pseudotuberculosis. the expression of aspartase (aspa) was confirmed to be increased at acidic ph by proteomic and lacz fusion analyses. addition of aspartate increased acid survival of the wild type but not the aspa knockout mutant. aspa increases acid survival by producing ammonia as demonstrated by mutation and in vitro enzyme activity analyses. this is the first demonstration that an enzyme involved in aspartate metabolism plays a role in acid survival in an enteric bacterium. (c) 2010 federation of european biochemical societies. published by elsevier b. v. all rights reserved. |
| WOS关键词 | ESCHERICHIA-COLI ; SALMONELLA-TYPHIMURIUM ; TOLERANCE RESPONSE ; RESISTANCE SYSTEMS ; SHIGELLA-FLEXNERI ; PH RESPONSE ; GLUTAMATE ; EXPRESSION ; IDENTIFICATION ; GADE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000277793200023 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375785 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Chen, Shiyun |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Yangbo,Lu, Pei,Zhang, Yong,et al. Characterization of an aspartate-dependent acid survival system in yersinia pseudotuberculosis[J]. Febs letters,2010,584(11):2311-2314. |
| APA | Hu, Yangbo,Lu, Pei,Zhang, Yong,Li, Lamei,&Chen, Shiyun.(2010).Characterization of an aspartate-dependent acid survival system in yersinia pseudotuberculosis.Febs letters,584(11),2311-2314. |
| MLA | Hu, Yangbo,et al."Characterization of an aspartate-dependent acid survival system in yersinia pseudotuberculosis".Febs letters 584.11(2010):2311-2314. |
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来源：武汉病毒研究所
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