C-c chemokine receptor type 5 (ccr5) utilization of transmitted and early founder human immunodeficiency virus type 1 envelopes and sensitivity to small-molecule ccr5 inhibitors
文献类型：期刊论文
| 作者 | Hu, Qinxue1,2; Huang, Xin2; Shattock, Robin J.1 |
| 刊名 | Journal of general virology
 |
| 出版日期 | 2010-12-01 |
| 卷号 | 91页码:2965-2973 |
| ISSN号 | 0022-1317 |
| DOI | 10.1099/vir.0.025270-0 |
| 通讯作者 | Shattock, robin j.() |
| 英文摘要 | The envelope glycoprotein (env) of human immunodeficiency virus is key to viral entry of susceptible target cells and is therefore a major target for the design of vaccines and antiviral drugs c-c chemokine receptor type 5 (ccr5)-using (r5) env is the predominant phenotype associated with early transmission and acute infection this study investigated the mechanism of ccr5 use and the sensitivity to ccr5 inhibitors of a panel of transmitted or early founder (t/f) envs the data showed that the majority of t/f envs used ccr5 and that many also used ccr3, although less efficiently despite a similar ability to use wild-type ccr5, individual envs differed significantly in their sensitivity to the ccr5 inhibitors maraviroc, cmpd-167 and sch-412147 inhibitor mapping experiments demonstrated that maraviroc cmpd-167 and sch-412147 interfered with the binding of ccr5 mab to the c-terminal half of the second extracellular loop 2 of ccr5 interestingly, envs resistant to maraviroc, cmpd167 and sch-412147 remained sensitive to tak-779 further studies indicated that the sensitivity of envs to ccr5 inhibitors correlated with the molecular anatomy of ccr5 use, revealing that the inhibitor-sensitive envs barely used the ccr5 n terminus, whereas resistant envs showed a marked increase in its use taken together, these findings demonstrate that t/f r5 envs are heterogeneous with respect to the mechanisms of ccr5 utilization these data may have implications for therapeutic and prophylactic use of ccr5-based antiretrovirals |
| WOS关键词 | CORECEPTOR ANTAGONIST VICRIVIROC ; HIV-1 INFECTION ; ENTRY INHIBITORS ; RESISTANCE ; FUSION ; GP120 ; DETERMINANTS ; SUBTYPE ; IDENTIFICATION ; SPECIFICITY |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Virology |
| WOS类目 | Biotechnology & Applied Microbiology ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000285221000009 |
| 出版者 | SOC GENERAL MICROBIOLOGY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375789 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Shattock, Robin J. |
| 作者单位 | 1.St Georges Univ London, Ctr Infect & Immun, London SW17 0RE, England 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Qinxue,Huang, Xin,Shattock, Robin J.. C-c chemokine receptor type 5 (ccr5) utilization of transmitted and early founder human immunodeficiency virus type 1 envelopes and sensitivity to small-molecule ccr5 inhibitors[J]. Journal of general virology,2010,91:2965-2973. |
| APA | Hu, Qinxue,Huang, Xin,&Shattock, Robin J..(2010).C-c chemokine receptor type 5 (ccr5) utilization of transmitted and early founder human immunodeficiency virus type 1 envelopes and sensitivity to small-molecule ccr5 inhibitors.Journal of general virology,91,2965-2973. |
| MLA | Hu, Qinxue,et al."C-c chemokine receptor type 5 (ccr5) utilization of transmitted and early founder human immunodeficiency virus type 1 envelopes and sensitivity to small-molecule ccr5 inhibitors".Journal of general virology 91(2010):2965-2973. |
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来源：武汉病毒研究所
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