Angiotensin-converting enzyme 2 (ace2) proteins of different bat species confer variable susceptibility to sars-cov entry
文献类型：期刊论文
| 作者 | Hou, Yuxuan1; Peng, Cheng1; Yu, Meng2; Li, Yan1; Han, Zhenggang1; Li, Fang3; Wang, Lin-Fa2; Shi, Zhengli1 |
| 刊名 | Archives of virology
 |
| 出版日期 | 2010-10-01 |
| 卷号 | 155期号:10页码:1563-1569 |
| ISSN号 | 0304-8608 |
| DOI | 10.1007/s00705-010-0729-6 |
| 通讯作者 | Shi, zhengli(zlshi@wh.iov.cn) |
| 英文摘要 | The discovery of sars-like coronavirus in bats suggests that bats could be the natural reservoir of sars-cov. however, previous studies indicated the angiotensin-converting enzyme 2 (ace2) protein, a known sars-cov receptor, from a horseshoe bat was unable to act as a functional receptor for sars-cov. here, we extended our previous study to ace2 molecules from seven additional bat species and tested their interactions with human sars-cov spike protein using both hiv-based pseudotype and live sars-cov infection assays. the results show that ace2s of myotis daubentoni and rhinolophus sinicus support viral entry mediated by the sars-cov s protein, albeit with different efficiency in comparison to that of the human ace2. further, the alteration of several key residues either decreased or enhanced bat ace2 receptor efficiency, as predicted from a structural modeling study of the different bat ace2 molecules. these data suggest that m. daubentoni and r. sinicus are likely to be susceptible to sars-cov and may be candidates as the natural host of the sars-cov progenitor viruses. furthermore, our current study also demonstrates that the genetic diversity of ace2 among bats is greater than that observed among known sars-cov susceptible mammals, highlighting the possibility that there are many more uncharacterized bat species that can act as a reservoir of sars-cov or its progenitor viruses. this calls for continuation and expansion of field surveillance studies among different bat populations to eventually identify the true natural reservoir of sars-cov. |
| WOS关键词 | ACUTE RESPIRATORY SYNDROME ; SYNDROME CORONAVIRUS ; HORSESHOE BATS ; RECEPTOR ; HUMANS ; ORIGIN ; CIVETS ; SPIKE |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000282426800002 |
| 出版者 | SPRINGER WIEN |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375804 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Shi, Zhengli |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 2.Commonwealth Sci & Ind Res Org Livestock Ind, Australian Anim Hlth Lab, Geelong, Vic 3220, Australia 3.Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA |
| 推荐引用方式 GB/T 7714 | Hou, Yuxuan,Peng, Cheng,Yu, Meng,et al. Angiotensin-converting enzyme 2 (ace2) proteins of different bat species confer variable susceptibility to sars-cov entry[J]. Archives of virology,2010,155(10):1563-1569. |
| APA | Hou, Yuxuan.,Peng, Cheng.,Yu, Meng.,Li, Yan.,Han, Zhenggang.,...&Shi, Zhengli.(2010).Angiotensin-converting enzyme 2 (ace2) proteins of different bat species confer variable susceptibility to sars-cov entry.Archives of virology,155(10),1563-1569. |
| MLA | Hou, Yuxuan,et al."Angiotensin-converting enzyme 2 (ace2) proteins of different bat species confer variable susceptibility to sars-cov entry".Archives of virology 155.10(2010):1563-1569. |
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来源：武汉病毒研究所
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