Identification of key amino acid residues required for horseshoe bat angiotensin-i converting enzyme 2 to function as a receptor for severe acute respiratory syndrome coronavirus
文献类型：期刊论文
| 作者 | Yu, Meng1; Tachedjian, Mary1; Cramen, Gary1; Shi, Zhengli2; Wang, Lin-Fa1 |
| 刊名 | Journal of general virology
 |
| 出版日期 | 2010-07-01 |
| 卷号 | 91页码:1706-1710 |
| ISSN号 | 0022-1317 |
| DOI | 10.1099/vir.0.020172-0 |
| 通讯作者 | Wang, lin-fa(linfa.wang@csiro.au) |
| 英文摘要 | Angiotensin-i converting enzyme 2 (ace2) is the receptor for severe acute respiratory syndrome (sars) coronavirus (sars-cov). a previous study indicated that ace2 from a horseshoe bat, the host of a highly related sars-like coronavirus, could not function as a receptor for sars-cov. here, we demonstrate that a 3 aa change from she (aa 40-42) to fyq was sufficient to convert the bat ace2 into a fully functional receptor for sars-cov. we further demonstrate that an ace2 molecule from a fruit bat, which contains the fyq motif, was able to support sars-cov infection, indicating a potentially much wider host range for sars-cov-related viruses among different bat populations. |
| WOS关键词 | SARS CORONAVIRUS ; PHYLOGEOGRAPHY ; CIVETS ; ENTRY ; SPIKE ; CHINA ; ACE2 |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Virology |
| WOS类目 | Biotechnology & Applied Microbiology ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000279747600007 |
| 出版者 | SOC GENERAL MICROBIOLOGY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375810 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Wang, Lin-Fa |
| 作者单位 | 1.CSIRO Livestock Ind, Australian Anim Hlth Lab, Geelong, Vic 3220, Australia 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Meng,Tachedjian, Mary,Cramen, Gary,et al. Identification of key amino acid residues required for horseshoe bat angiotensin-i converting enzyme 2 to function as a receptor for severe acute respiratory syndrome coronavirus[J]. Journal of general virology,2010,91:1706-1710. |
| APA | Yu, Meng,Tachedjian, Mary,Cramen, Gary,Shi, Zhengli,&Wang, Lin-Fa.(2010).Identification of key amino acid residues required for horseshoe bat angiotensin-i converting enzyme 2 to function as a receptor for severe acute respiratory syndrome coronavirus.Journal of general virology,91,1706-1710. |
| MLA | Yu, Meng,et al."Identification of key amino acid residues required for horseshoe bat angiotensin-i converting enzyme 2 to function as a receptor for severe acute respiratory syndrome coronavirus".Journal of general virology 91(2010):1706-1710. |
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来源：武汉病毒研究所
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