The wild-type hepatitis c virus core inhibits initiation of antigen-specific t- and b-cell immune responses in balb/c mice
文献类型：期刊论文
| 作者 | Zhu, Wenbo1,4; Chang, Yanzi2; Wu, Chunchen1; Han, Qingxia1; Pei, Rongjuan1,4; Lu, Mengji1,2,3; Chen, Xinwen1 |
| 刊名 | Clinical and vaccine immunology
 |
| 出版日期 | 2010-07-01 |
| 卷号 | 17期号:7页码:1139-1147 |
| ISSN号 | 1556-6811 |
| DOI | 10.1128/cvi.00490-09 |
| 通讯作者 | Chen, xinwen(chenxw@pentium.whiov.ac.cn) |
| 英文摘要 | In this study, the effects of wild-type and deletion mutant hepatitis c virus (hcv) core proteins on the induction of immune responses in balb/c mice were assessed. p2ha-c145-s23, encoding a core protein with the c-terminal 46 amino acids truncated, significantly produced stronger antibody and cellular responses than p2ha-c191-s23. the induction of immune responses by p2ha-c145-s23 was dose dependent. however, increasing the doses or repeated administration did not enhance immune responses by the wild-type core protein. in addition, p2ha-c191-s23 was apparently able to interfere with the priming of specific immune responses by p2ha-c145-s23 when the two were coadministered. these results demonstrated that the wild-type hcv core protein itself could inhibit the priming of immune responses in the course of a dna vaccination, whereas the truncated hcv core protein could provide potential applications for the development of dna-and peptide-based hcv vaccines. |
| WOS关键词 | DENDRITIC CELLS ; SUBCELLULAR-LOCALIZATION ; LYMPHOCYTE RESPONSE ; ENVELOPE PROTEIN ; IN-VIVO ; INFECTION ; IMMUNIZATION ; GENE ; ACTIVATION ; SUPPRESSION |
| WOS研究方向 | Immunology ; Infectious Diseases ; Microbiology |
| WOS类目 | Immunology ; Infectious Diseases ; Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000280536700012 |
| 出版者 | AMER SOC MICROBIOLOGY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375839 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Chen, Xinwen |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Pathogen Biol, Div Microbiol, Wuhan 430074, Peoples R China 3.Univ Hosp Essen, Inst Virol, D-45122 Essen, Germany 4.Chinese Acad Sci, Grad Univ, Beijing 10039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Wenbo,Chang, Yanzi,Wu, Chunchen,et al. The wild-type hepatitis c virus core inhibits initiation of antigen-specific t- and b-cell immune responses in balb/c mice[J]. Clinical and vaccine immunology,2010,17(7):1139-1147. |
| APA | Zhu, Wenbo.,Chang, Yanzi.,Wu, Chunchen.,Han, Qingxia.,Pei, Rongjuan.,...&Chen, Xinwen.(2010).The wild-type hepatitis c virus core inhibits initiation of antigen-specific t- and b-cell immune responses in balb/c mice.Clinical and vaccine immunology,17(7),1139-1147. |
| MLA | Zhu, Wenbo,et al."The wild-type hepatitis c virus core inhibits initiation of antigen-specific t- and b-cell immune responses in balb/c mice".Clinical and vaccine immunology 17.7(2010):1139-1147. |
入库方式： iSwitch采集
来源：武汉病毒研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。