In vitro inhibitory effect of carrageenan oligosaccharide on influenza a h1n1 virus
文献类型：期刊论文
| 作者 | Wang, Wei1,2; Zhang, Pan2; Hao, Cui2; Zhang, Xian-En3; Cui, Zong-Qiang3; Guan, Hua-Shi2 |
| 刊名 | Antiviral research
 |
| 出版日期 | 2011-11-01 |
| 卷号 | 92期号:2页码:237-246 |
| 关键词 | Influenza a virus Carrageenan oligosaccharide Adsorption Internalization Cell surface |
| ISSN号 | 0166-3542 |
| DOI | 10.1016/j.antiviral.2011.08.010 |
| 通讯作者 | Wang, wei(wangweidragon@yahoo.com.cn) |
| 英文摘要 | Carrageenan polysaccharide has been reported to be able to inhibit the infection and replication of many different kinds of viruses. here, we demonstrated that a 2 kda kappa-carrageenan oligosaccharide (co-1) derived from the carrageenan polysaccharide, effectively inhibited influenza a (h1n1) virus replication in mdck cells (selectivity index >25.0). moreover, the 2 kda co-1 inhibited influenza a virus (iav) replication better than that of 3 kda and 5 kda kappa-carrageenan oligosaccharides (co-2 and co-3). iav multiplication was suppressed by carrageenan oligosaccharide treatment in a dose-dependent manner. carrageenan oligosaccharide co-1 did not bind to the cell surface of mdck cells but inactivated virus particles after pretreatment. different to the actions of carrageenan polysaccharide, co-1 could enter into mdck cells and did not interfere with iav adsorption. co-1 also inhibited iav mrna and protein expression after its internalization into cells. moreover, carrageenan oligosaccharide co-1 had an antiviral effect on iav replication subsequent to viral internalization but prior to virus release in one replication cycle. therefore, inhibition of iav intracellular replication by carrageenan oligosaccharide might be an alternative approach for anti-influenza a virus therapy. (c) 2011 elsevier b.v. all rights reserved. |
| WOS关键词 | HERPES-SIMPLEX-VIRUS ; MOLECULAR-WEIGHT CARRAGEENANS ; ANTI-HIV ACTIVITY ; ANTIVIRAL ACTIVITY ; INFECTION ; CELL ; AGENTS ; ENTRY ; POLYSACCHARIDES ; HEMAGGLUTININ |
| WOS研究方向 | Pharmacology & Pharmacy ; Virology |
| WOS类目 | Pharmacology & Pharmacy ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000297427200012 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375846 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Wang, Wei |
| 作者单位 | 1.Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China 2.Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycotechnol, Qingdao 266003, Peoples R China 3.Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Wei,Zhang, Pan,Hao, Cui,et al. In vitro inhibitory effect of carrageenan oligosaccharide on influenza a h1n1 virus[J]. Antiviral research,2011,92(2):237-246. |
| APA | Wang, Wei,Zhang, Pan,Hao, Cui,Zhang, Xian-En,Cui, Zong-Qiang,&Guan, Hua-Shi.(2011).In vitro inhibitory effect of carrageenan oligosaccharide on influenza a h1n1 virus.Antiviral research,92(2),237-246. |
| MLA | Wang, Wei,et al."In vitro inhibitory effect of carrageenan oligosaccharide on influenza a h1n1 virus".Antiviral research 92.2(2011):237-246. |
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来源：武汉病毒研究所
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