Characterization of the subcellular localization of herpes simplex virus type 1 proteins in living cells
文献类型：期刊论文
| 作者 | Xing, Junji; Wang, Shuai; Li, You; Guo, Hong; Zhao, Lei; Pan, Weiwei; Lin, Fusen; Zhu, Huifang; Wang, Lei; Li, Meili |
| 刊名 | Medical microbiology and immunology
 |
| 出版日期 | 2011-02-01 |
| 卷号 | 200期号:1页码:61-68 |
| 关键词 | Subcellular localization Herpes simplex virus type 1 proteins Living cell microscopy |
| ISSN号 | 0300-8584 |
| DOI | 10.1007/s00430-010-0175-9 |
| 通讯作者 | Zheng, chunfu(zheng.alan@hotmail.com) |
| 英文摘要 | In this study, we presented the construction of a library of expression clones for the herpes simplex virus type 1 (hsv-1) proteome and subcellular localization map of hsv-1 proteins in living cells using yellow fluorescent protein (yfp) fusion proteins. as a result, 21 proteins showed cytoplasmic or subcytoplasmic localization, 16 proteins showed nuclear or subnuclear localization, and others were present both in the nucleus and cytoplasm. interestingly, most capsid proteins showed enriched or exclusive localization in the nucleus, and most of the envelope proteins showed cytoplasmic localization, suggesting that subcellular localization of the proteins correlated with their functions during virus replication. these results present a subcellular localization map of hsv-1 proteins in living cells, which provide useful information to further characterize the functions of these proteins. |
| WOS关键词 | ORIGIN-BINDING PROTEIN ; OPEN READING FRAME ; GENE-PRODUCT ; TEGUMENT PROTEIN ; INTRACELLULAR-LOCALIZATION ; NUCLEAR-LOCALIZATION ; INFECTED-CELLS ; CAPSID PROTEINS ; VIRAL-DNA ; PUTATIVE TERMINASE |
| WOS研究方向 | Immunology ; Microbiology |
| WOS类目 | Immunology ; Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000286202700008 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375849 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zheng, Chunfu |
| 作者单位 | Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xing, Junji,Wang, Shuai,Li, You,et al. Characterization of the subcellular localization of herpes simplex virus type 1 proteins in living cells[J]. Medical microbiology and immunology,2011,200(1):61-68. |
| APA | Xing, Junji.,Wang, Shuai.,Li, You.,Guo, Hong.,Zhao, Lei.,...&Zheng, Chunfu.(2011).Characterization of the subcellular localization of herpes simplex virus type 1 proteins in living cells.Medical microbiology and immunology,200(1),61-68. |
| MLA | Xing, Junji,et al."Characterization of the subcellular localization of herpes simplex virus type 1 proteins in living cells".Medical microbiology and immunology 200.1(2011):61-68. |
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来源：武汉病毒研究所
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